| Cascade of levodopa dose and weight-related dyskinesia in Parkinson's disease (LD-WD-PD cascade). | |
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MedLine Citation:
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PMID: 16935018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have studied a cohort of 220 Parkinson's disease (PD) patients for risk factors of developing new dyskinesia. Twenty-nine patients were noticed to have developed new dyskinesia at the second assessment. The dyskinetic patients received significantly higher maximum level daily dose of levodopa. These patients had lost weight during the course of the disease from 72+/-15 to 66+/-17kg, p=0.002. The dyskinetic patients received significantly higher daily dose of levodopa per kilogram body weight, 8.4+/-3.5mg/kg vs. 6.0+/-3.9mg, p=0.003. Weight-losers PD patients developed significantly more dyskinesia than non-weight losers-p=0.002. Logistic regression analysis revealed weight loss and daily levodopa dose per kilogram body weight to be the only significant factors for dyskinesia in addition to disease duration. There was a "dose response to developing dyskinesia" according to the increasing levodopa dose per kilogram body weight. |
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Authors:
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Jagdish C Sharma; Lorna Macnamara; Mohammad Hasoon; Michael Vassallo; Ian Ross |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2006-08-28 |
Journal Detail:
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Title: Parkinsonism & related disorders Volume: 12 ISSN: 1353-8020 ISO Abbreviation: Parkinsonism Relat. Disord. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-29 Completed Date: 2007-02-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513583 Medline TA: Parkinsonism Relat Disord Country: England |
Other Details:
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Languages: eng Pagination: 499-505 Citation Subset: IM |
Affiliation:
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Parkinson's Disease Services, Sherwood Forest Hospitals NHS Trust, Bournemouth, BH7 7 DW, UK. Jagdish.Sharma@sfh-tr.nhs.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Antiparkinson Agents / adverse effects* Cohort Studies Dose-Response Relationship, Drug Dyskinesia, Drug-Induced / etiology* Female Humans Levodopa / adverse effects* Logistic Models Male Parkinson Disease / drug therapy, physiopathology Retrospective Studies Risk Factors Sex Factors Weight Loss* / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antiparkinson Agents; 0/Levodopa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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