Document Detail

Carvedilol prevents ovariectomy-induced myocardial contractile dysfunction in female rat.
MedLine Citation:
PMID:  23308166     Owner:  NLM     Status:  MEDLINE    
Carvedilol has beneficial effects on cardiac function in patients with heart failure but its effect on ovariectomy-induced myocardial contractile dysfunction remains unclear. Estrogen deficiency induces myocardial contractile dysfunction and increases cardiovascular disease risk in postmenopausal women. Our aim was to investigate whether carvedilol, a beta receptor blocker, would prevent ovariectomy-induced myocardial contractile dysfunction. Female rats (8 weeks old) that underwent bilateral ovariectomy were randomly assigned to receive daily treatment with carvedilol (OVX+CAR, 20 mg/kg), placebo (OVX) and SHAM for 58 days. Left ventricle papillary muscle was mounted for isometric tension recordings. The inotropic response to Ca(2+) (0.62 to 3.75 mM) and isoproterenol (Iso 10(-8) to 10(-2 )M) were assessed. Expression of calcium handling proteins was measured by western blot analysis. Carvedilol treatment in the OVX animals: prevented weight gain and slight hypertrophy, restored the reduced positive inotropic responses to Ca(2+) and isoproterenol, prevented the reduction in SERCA2a expression, abolished the increase in superoxide anion production, normalized the increase in p22(phox) expression, and decreased serum angiotensin converting enzyme (ACE) activity. This study demonstrated that myocardial contractile dysfunction and SERCA2a down regulation were prevented by carvedilol treatment. Superoxide anion production and NADPH oxidase seem to be involved in this response.
Rogerio Faustino Ribeiro; Felipe F Potratz; Brunella M M Pavan; Ludimila Forechi; Filipe Lugon Moulin Lima; Jonaina Fiorim; Aurelia Araujo Fernandes; Dalton Valentim Vassallo; Ivanita Stefanon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-07
Journal Detail:
Title:  PloS one     Volume:  8     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-11     Completed Date:  2013-07-01     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e53226     Citation Subset:  IM    
Department of Physiological Sciences, Federal University of Espirito Santo, Vitoria, Brazil.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Body Weight / drug effects
Calcium / metabolism
Carbazoles / therapeutic use*
Heart / drug effects*,  physiopathology
Heart Diseases / blood,  etiology,  physiopathology,  prevention & control*
Hemodynamics / drug effects
Malondialdehyde / blood
Myocardial Contraction / drug effects*
Myocardium / metabolism,  pathology*
Organ Size / drug effects
Ovariectomy / adverse effects*
Peptidyl-Dipeptidase A / blood
Propanolamines / therapeutic use*
Rats, Wistar
Receptors, Adrenergic, beta / metabolism
Superoxides / metabolism
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 0/Receptors, Adrenergic, beta; 0K47UL67F2/carvedilol; 11062-77-4/Superoxides; 542-78-9/Malondialdehyde; 7440-70-2/Calcium; EC A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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