Document Detail


Carvedilol increases the systemic bioavailability of oral digoxin.
MedLine Citation:
PMID:  1970265     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of a single oral dose of 25 mg carvedilol on the plasma and urinary kinetics of digoxin after an oral and intravenous 0.5 mg dose, were investigated in two separate double-blind, placebo-controlled, period-balanced cross-over studies in healthy male subjects. Carvedilol increased the mean maximum plasma concentration and the area under the plasma concentration time-curve of digoxin when administered orally. The effects were virtually confined to the first 4 h after dosing, and the apparent terminal disposition rate constant was not changed. Carvedilol did not alter the plasma and urinary kinetics of intravenously administered digoxin.
Authors:
C De Mey; E Brendel; D Enterling
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  29     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-05-30     Completed Date:  1990-05-30     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  486-90     Citation Subset:  IM    
Affiliation:
SK & F-Institute for Applied Clinical Pharmacology, SKD, Göttingen, FRG.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adrenergic beta-Antagonists / pharmacology*
Adult
Biological Availability
Carbazoles / pharmacology*
Digoxin / administration & dosage,  pharmacokinetics*
Double-Blind Method
Drug Interactions
Electrocardiography
Humans
Injections, Intravenous
Male
Propanolamines / pharmacology*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 0K47UL67F2/carvedilol; 20830-75-5/Digoxin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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