| Carvedilol Reduces Aortic Wave Reflection and Improves Left Ventricular/Vascular Coupling: A Comparison With Atenolol (CENTRAL Study). | |
| | |
MedLine Citation:
|
PMID: 22142351 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
J Clin Hypertens (Greenwich). 2011;13:917-924. ©2011 Wiley Periodicals, Inc. Blood pressure (BP) characteristics, such as central aortic pressure and arterial stiffness, independently predict cardiovascular events. The effects of pharmacologically dissimilar β-blockers on these properties have not been fully elucidated. Patients with essential hypertension and without significant concomitant cardiovascular disease were randomly assigned to controlled-release carvedilol, force-titrated to 80 mg (n=22), or atenolol, force-titrated to 100 mg (n=19); each was given once daily for 4 weeks. Baseline characteristics were similar. At the end of week 4, atenolol and carvedilol reduced central and brachial systolic and diastolic BP to a similar extent. Central augmentation index was increased in atenolol-treated patients but not carvedilol-treated patients (atenolol 4.47% vs carvedilol -0.68%; P=.04). Mean augmented central aortic pressure increased slightly during atenolol treatment (+1.1 mm Hg) but decreased slightly during carvedilol treatment (-1.1 mm Hg), although the difference in these changes was not statistically significant (P=.23). Pulse pressure amplification was reduced more with atenolol at week 4 (atenolol -10.7% vs carvedilol -1.8%; P=.02). Therefore, we conclude that carvedilol results in more favorable pulse pressure amplification and augmentation index by increasing arterial compliance and reducing the magnitude of wave reflection, respectively, compared with atenolol. |
| | |
Authors:
|
Niren K Shah; Steven M Smith; Wilmer W Nichols; Margaret C Lo; Umna Ashfaq; Priya Satish; Julie A Johnson; Benjamin J Epstein |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-7 |
Journal Detail:
|
Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 13 ISSN: 1751-7176 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: - |
Other Details:
|
Languages: ENG Pagination: 917-924 Citation Subset: - |
Copyright Information:
|
© 2011 Wiley Periodicals, Inc. |
Affiliation:
|
From the East Coast Institute for Research, Jacksonville, FL;the School of Pharmacy and Department of Clinical Pharmacy, University of Colorado Denver, Aurora, CO;the College of Medicine, Department of Medicine, Division of Medicine, University of Florida, Gainesville, FL;the Division of Cardiovascular Medicine and Department of Pharmacy Practice, University of Florida, Gainesville, FL;the College of Pharmacy and Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluation of the migraine treatment sumatriptan/naproxen sodium on blood pressure following long-te...
Next Document: Relationship Between Body Mass Index and High Cystatin Levels Among US Adults.