| Carvedilol-Lisinopril Combination Therapy and Endothelial Function in Obese Individuals With Hypertension. | |
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MedLine Citation:
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PMID: 22277140 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The authors hypothesized that carvedilol controlled-release plus lisinopril combination therapy (C+L) would increase endothelial function and decrease oxidative stress to a greater extent than hydrochlorothiazide plus lisinopril combination therapy (H+L) in obese patients with hypertension. Twenty-five abdominally obese patients (aged 54.4±7.3 years; 14 women) with hypertension/prehypertension were enrolled in a 7-month (two 3-month treatment periods separated by a 1-month washout), randomized, double-blind, controlled, crossover clinical trial comparing C+L vs H+L. Endothelial function, measured by digital reactive hyperemic index (RHI), circulating oxidized low-density lipoprotein (oxLDL), 8-isoprostane, and asymmetric dimethylarginine (ADMA) were obtained at baseline, post-period 1, post-washout, and post-period 2. Analyses were adjusted for baseline measurements by analysis of covariance, with robust variance estimation for confidence intervals and P values. C+L treatment compared to H+L treatment significantly improved RHI (0.74, 95% confidence interval, 0.31-1.19, P =.001). This difference persisted after adjustment for the change in systolic blood pressure. No significant treatment differences were observed for oxLDL, 8-isoprostane, or ADMA. These data provide evidence that independent of blood pressure-lowering, C+L therapy improves endothelial function to a greater extent than H+L therapy. Levels of oxidative stress were not significantly different between treatments, suggesting that other mechanisms may be responsible for the improvement in endothelial function. |
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Authors:
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Aaron S Kelly; J Michael Gonzalez-Campoy; Kyle D Rudser; Harold Katz; Andrea M Metzig; Melissa Thalin; Alan J Bank |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-19 |
Journal Detail:
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Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 14 ISSN: 1751-7176 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-1-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: - |
Other Details:
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Languages: ENG Pagination: 85-91 Citation Subset: - |
Copyright Information:
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© 2011 Wiley Periodicals, Inc. |
Affiliation:
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From the Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN ; 1 Minnesota Center for Obesity, Metabolism and Endocrinology, Eagan, MN ; 2 the Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN ; 3 Allina Hospitals and Clinics, St. Paul, MN ; 4 and the Department of Research, St. Paul Heart Clinic, St. Paul, MN 5. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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