Document Detail


Cartilage regeneration by selected chondrogenic clonal mesenchymal stem cells in the collagenase-induced monkey osteoarthritis model.
MedLine Citation:
PMID:  23335439     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Osteoarthritis (OA) is the most common form of arthritis, in which cartilage is irreversibly degraded, causing severe pain and disability. Current therapeutic strategies cannot repair damaged cartilage. We evaluated the repair potential of selected chondrogenic clonal MSCs (sC-MSCs) by delivering them into the injured cartilage site in a collagenase-induced OA model in Cynomolgus monkeys. In vitro characterization showed that the isolated monkey sC-MSCs and polyclonal MSCs (P-MSCs) expressed mesenchymal stem cell markers and could differentiate into chondrocytes. The articular cartilage lesions in animals were treated with normal saline (NS), autologous P-MSCs and sC-MSCs, respectively, by direct delivery. The clinical parameters, radiographic images, histological and immunohistochemical examinations at weeks 8, 16 and 24 post-treatment demonstrated that the abrasions of articular cartilage were significantly improved and repaired by MSC-based treatment, particularly in the sC-MSC-treated group, which displayed consistently higher histological scores than those of other groups. In summary, treatment with sC-MSCs can effectively improve the healing of cartilage lesions in the Cynomolgus monkey collagenase-induced OA model. Due to the genetic proximity of monkey and human, the therapeutic strategy presented in this study will have broad applications in clinical practice. Copyright © 2013 John Wiley & Sons, Ltd.
Authors:
Li Jiang; Anlun Ma; Lijun Song; Yanxin Hu; Hao Dun; Pierre Daloze; Yonglin Yu; Jianyuan Jiang; Muhammad Zafarullah; Huifang Chen
Related Documents :
23433779 - Immune surveillance for eraap dysfunction.
23044069 - Evaluation of a xeno-free protocol for long-term cryopreservation of cord blood cells.
22988969 - Gene therapy of malignant solid tumors by targeting erbb2 receptors and by activating t...
23260439 - Bioprinting for stem cell research.
22959759 - Follicular t-cell lymphoma: a member of an emerging family of follicular helper t-cell ...
23822619 - Hepatic progenitor cell inhibition during embryonic period with high dose verapamil; li...
16176929 - Btk plays a crucial role in the amplification of fc epsilonri-mediated mast cell activa...
18525269 - Hiv gag-specific immune responses predict the rate of cd4 decline.
16036109 - The minimal set of genetic alterations required for conversion of primary human fibrobl...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-21
Journal Detail:
Title:  Journal of tissue engineering and regenerative medicine     Volume:  -     ISSN:  1932-7005     ISO Abbreviation:  J Tissue Eng Regen Med     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101308490     Medline TA:  J Tissue Eng Regen Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 John Wiley & Sons, Ltd.
Affiliation:
Department of Surgery, CRCHUM, Notre Dame Hospital, University of Montreal, Quebec, Canada; Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Polymeric Systems Incorporating Plant Viral Nanoparticles for Tailored Release of Therapeutics.
Next Document:  Netrin-1 Pretreatment Protects Rat Kidney against Ischemia/Reperfusion Injury via Suppression of Oxi...