| Cartilage quality in rheumatoid arthritis: comparison of T2* mapping, native T1 mapping, dGEMRIC, ΔR1 and value of pre-contrast imaging. | |
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MedLine Citation:
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PMID: 21932053 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To prospectively evaluate four non-invasive markers of cartilage quality-T2* mapping, native T1 mapping, dGEMRIC and ΔR1-in healthy volunteers and rheumatoid arthritis (RA) patients. MATERIALS AND METHODS: Cartilage of metacarpophalangeal (MCP) joints II were imaged in 28 consecutive subjects: 12 healthy volunteers [9 women, mean (SD) age 52.67 (9.75) years, range 30-66] and 16 RA patients with MCP II involvement [12 women, mean (SD) age 58.06 (12.88) years, range 35-76]. Sagittal T2* mapping was performed with a multi-echo gradient-echo on a 3 T MRI scanner. For T1 mapping the dual flip angle method was applied prior to native T1 mapping and 40 min after gadolinium application (delayed gadolinium-enhanced MRI of cartilage, dGEMRIC, T1(Gd)). The difference in the longitudinal relaxation rate induced by gadolinium (ΔR1) was calculated. The area under the receiver operating characteristic curve (AROC) was used to test for differentiation of RA patients from healthy volunteers. RESULTS: dGEMRIC (AUC 0.81) and ΔR1 (AUC 0.75) significantly differentiated RA patients from controls. T2* mapping (AUC 0.66) and native T1 mapping (AUC 0.66) were not significantly different in RA patients compared to controls. CONCLUSIONS: The data support the use of dGEMRIC for the assessment of MCP joint cartilage quality in RA. T2* and native T1 mapping are of low diagnostic value. Pre-contrast T1 mapping for the calculation of ΔR1 does not increase the diagnostic value of dGEMRIC. |
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Authors:
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Christian Buchbender; Axel Scherer; Patric Kröpil; Birthe Körbl; Michael Quentin; Dorothea Ch Reichelt; Rotem S Lanzman; Christian Mathys; Dirk Blondin; Bernd Bittersohl; Christoph Zilkens; Matthias Hofer; Hans-Jörg Wittsack; Matthias Schneider; Gerald Antoch; Benedikt Ostendorf; Falk Miese |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-20 |
Journal Detail:
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Title: Skeletal radiology Volume: - ISSN: 1432-2161 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7701953 Medline TA: Skeletal Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Diagnostic and Interventional Radiology, Medical Faculty, University Düsseldorf, D-40225, Düsseldorf, Germany, Christian.buchbender@med.uni-duesseldorf.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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