Document Detail

[Cartilage quality in finger joints: delayed Gd(DTPA)²-enhanced MRI of the cartilage (dGEMRIC) at 3T].
MedLine Citation:
PMID:  20725879     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the feasibility of molecular cartilage MRI in finger joints. MATERIALS AND METHODS: Delayed Gd(DTPA)²-enhanced MRI of the cartilage (dGEMRIC) using a variable flip angle approach (VFA) was performed for the metacarpophalangeal (MCP) joints II and III in nine healthy volunteers and eighteen patients with rheumatoid arthritis (RA). The cartilage thickness was measured. Additionally, dGEMRIC was performed on proximal interphalangeal joints (PIP) in two patients with finger osteoarthritis (OA). RESULTS: the dGEMRIC index of the four evaluated cartilage areas was significantly decreased in RA patients compared to healthy subjects. The dGEMRIC index of MCP II phalangeal cartilage was 389.6 ± 85.5 msec vs. 558.7 ± 74.4 msec in healthy subjects. The metacarpal MCP II cartilage dGEMRIC index was 357.3 msec ± 97.1 msec vs. 490.0 ± 86.6 msec. The dGEMRIC indices of MCP III were: phalangeal 436.2 ± 113.6 msec in RA, 558.8 ± 115.5 msec in healthy subjects and metacarpal 398.0 ± 97.6 msec in RA and 529.6 ± 111.0 msec in healthy subjects. Age and cartilage thickness were not significantly different. In PIP joints of finger osteoarthritis patients, low dGEMRIC indices were noted, compared to the controls. CONCLUSION: The dGEMRIC of finger joints is feasible in patients with RA and finger OA. Morphologically normal cartilage shows significantly decreased dGEMRIC values in RA, pointing towards cartilage degeneration on a molecular level. Further studies are needed to establish the usefulness of this technique for early diagnosis, prognosis and therapy monitoring.
F R Miese; B Ostendorf; H-J Wittsack; D C Reichelt; P Kröpil; R S Lanzman; T C Mamisch; C Zilkens; V Jellus; M Quentin; M Schneider; A Scherer
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Publication Detail:
Type:  English Abstract; Journal Article     Date:  2010-08-19
Journal Detail:
Title:  RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin     Volume:  182     ISSN:  1438-9010     ISO Abbreviation:  Rofo     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-05     Completed Date:  2010-10-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7507497     Medline TA:  Rofo     Country:  Germany    
Other Details:
Languages:  ger     Pagination:  873-8     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Institut für Radiologie, Heinrich-Heine Universität, Moorenstrasse 5, Düsseldorf.
Vernacular Title:
Knorpelqualität an den Fingergelenken: delayed Gd(DTPA)²-enhanced MRI of the cartilage (dGEMRIC) bei 3T.
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MeSH Terms
Arthritis, Rheumatoid / diagnosis*,  pathology
Cartilage, Articular / pathology*
Contrast Media / administration & dosage*
Feasibility Studies
Finger Joint / pathology*
Gadolinium DTPA / diagnostic use*
Glycosaminoglycans / metabolism
Image Processing, Computer-Assisted / methods*
Magnetic Resonance Imaging / methods*
Metacarpophalangeal Joint / pathology*
Middle Aged
Osteoarthritis / diagnosis*,  pathology
Reference Values
Sensitivity and Specificity
Reg. No./Substance:
0/Contrast Media; 0/Glycosaminoglycans; 80529-93-7/Gadolinium DTPA

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