| [Cartilage quality in finger joints: delayed Gd(DTPA)²-enhanced MRI of the cartilage (dGEMRIC) at 3T]. | |
| | |
MedLine Citation:
|
PMID: 20725879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To evaluate the feasibility of molecular cartilage MRI in finger joints. MATERIALS AND METHODS: Delayed Gd(DTPA)²-enhanced MRI of the cartilage (dGEMRIC) using a variable flip angle approach (VFA) was performed for the metacarpophalangeal (MCP) joints II and III in nine healthy volunteers and eighteen patients with rheumatoid arthritis (RA). The cartilage thickness was measured. Additionally, dGEMRIC was performed on proximal interphalangeal joints (PIP) in two patients with finger osteoarthritis (OA). RESULTS: the dGEMRIC index of the four evaluated cartilage areas was significantly decreased in RA patients compared to healthy subjects. The dGEMRIC index of MCP II phalangeal cartilage was 389.6 ± 85.5 msec vs. 558.7 ± 74.4 msec in healthy subjects. The metacarpal MCP II cartilage dGEMRIC index was 357.3 msec ± 97.1 msec vs. 490.0 ± 86.6 msec. The dGEMRIC indices of MCP III were: phalangeal 436.2 ± 113.6 msec in RA, 558.8 ± 115.5 msec in healthy subjects and metacarpal 398.0 ± 97.6 msec in RA and 529.6 ± 111.0 msec in healthy subjects. Age and cartilage thickness were not significantly different. In PIP joints of finger osteoarthritis patients, low dGEMRIC indices were noted, compared to the controls. CONCLUSION: The dGEMRIC of finger joints is feasible in patients with RA and finger OA. Morphologically normal cartilage shows significantly decreased dGEMRIC values in RA, pointing towards cartilage degeneration on a molecular level. Further studies are needed to establish the usefulness of this technique for early diagnosis, prognosis and therapy monitoring. |
| | |
Authors:
|
F R Miese; B Ostendorf; H-J Wittsack; D C Reichelt; P Kröpil; R S Lanzman; T C Mamisch; C Zilkens; V Jellus; M Quentin; M Schneider; A Scherer |
Related Documents
:
|
9873839 - Urinary n-acetyl-beta-d-glucosaminidase in rheumatoid arthritis. 10941819 - Lipoprotein(a) and lipids in relation to inflammation in rheumatoid arthritis. 20510319 - Effect of human leukocyte antigen class ii genes on acute-onset and slow-onset type 1 d... 20505629 - Ultrasonographic study of the painful shoulder in patients with rheumatoid arthritis an... 15108069 - Bone mineral density and urolithiasis interaction in rheumatoid arthritis. 23364139 - Amyloid pathology influences aβ1-42 cerebrospinal fluid levels in dementia with lewy b... 18426269 - Clinical implications of systemic inflammatory response syndrome following thoracic aor... 10533009 - Incidence of immediate and delayed hypersensitivity to centruroides antivenom. 17686109 - Relationship between aria classification and drug treatment in allergic rhinitis and as... |
Publication Detail:
|
Type: English Abstract; Journal Article Date: 2010-08-19 |
Journal Detail:
|
Title: RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin Volume: 182 ISSN: 1438-9010 ISO Abbreviation: Rofo Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-05 Completed Date: 2010-10-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7507497 Medline TA: Rofo Country: Germany |
Other Details:
|
Languages: ger Pagination: 873-8 Citation Subset: IM |
Copyright Information:
|
© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
|
Institut für Radiologie, Heinrich-Heine Universität, Moorenstrasse 5, Düsseldorf. falk.miese@med.uniduesseldorf.de |
Vernacular Title:
|
Knorpelqualität an den Fingergelenken: delayed Gd(DTPA)²-enhanced MRI of the cartilage (dGEMRIC) bei 3T. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Arthritis, Rheumatoid / diagnosis*, pathology Cartilage, Articular / pathology* Contrast Media / administration & dosage* Feasibility Studies Female Finger Joint / pathology* Gadolinium DTPA / diagnostic use* Glycosaminoglycans / metabolism Humans Image Processing, Computer-Assisted / methods* Magnetic Resonance Imaging / methods* Male Metacarpophalangeal Joint / pathology* Middle Aged Osteoarthritis / diagnosis*, pathology Reference Values Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Glycosaminoglycans; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: [Embolization of acute abdominal and thoracic hemorrhages with ethylene vinyl alcohol copolymer (Ony...
Next Document: Postoperative monitoring of distal intraarticular radial fractures treated with osteosynthesis by me...