Document Detail


Cartilage Oligomeric Matrix Protein - inflammation biomarker in knee osteoarthritis.
MedLine Citation:
PMID:  21342138     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Chondrocytes and synovial cells synthesize Cartilage Oligomeric Matrix Protein (COMP) when activated by proinflammatory cytokines. The aim of this study was to analyze and compare ultrasound parameters of joint inflammation, effusion and synovitis with the levels of COMP in the serum of patients with primary osteoarthritis. Ultrasound was done and the concentration of COMP (ng/mL was examined in 88 patients. 75% of patients had effusion (size 10.13±4.35 mm), 62.5% had effusion in lateral recessus (LR), 28.4% (size 8.53±2.27 mm) in suprapatelar (SR), and 27.3% (size 11.38±4.44 mm) in medial (MR). 67% of patients had synovitis size 4.84±3.57 mm in SR, 3.15±1.86 mm in MR; and 6.09±2.80 mm in LR. 17.0% of patients had nodular type of synovitis, 30.7% had diffusive, and 19.3% nodular - diffusive. There was a significant link between the size of synovitis and effusion in SR (r=0.966, p=0.000), MR (r=0.812, p=0.009) and LR (r=0.886, p=0.003). The median of COMP concentration was 54 (44.5-58) ng/mL in patients without effusion. In those with effusion it was 57 (48.75-64.25) ng/mL (p=0.030). Without synovitis it was 52 (45.5-58) ng/mL, with synovitis 58 (50-66) ng/mL, (p=0.006), diffusion type synovitis 60 (50-67) ng/mL, nodular 57 (50-62) ng/mL, nodular-diffusion 54 (44.5-66.5) ng/mL (p=0.014). With longer osteophytes the median of COMP was 56 (48-64) ng/mL, with shorter osteophytes 55 (46.5-59) ng/mL (p=0.000). Cartilage oligomeric matrix protein has a moderate significance in the assessment of disturbance of the metabolism of synovial and cartilage tissue in patients with knee osteoarthritis (sensitivity=59%; specificity=50%; cut off=53.5 ng/mL).
Authors:
Sandra Zivanović; Ljiljana Petrović Rackov; Aleksandar Zivanović; Milorad Jevtić; Sandra Nikolić; Sanja Kocić
Related Documents :
18330828 - Severe cutaneous adverse drug reaction to leflunomide: a report of two cases.
21120508 - Cytoplasmic accumulation of tdp-43 in circulating lymphomonocytes of als patients with ...
6192648 - Results of lymphography in early mycosis fungoides.
9674788 - Decreased type iv collagen of skin and serum in patients with amyotrophic lateral scler...
24180578 - Stable hemoglobin in hemodialysis patients: forest for the trees -- a 12-week pilot obs...
12166698 - Influence of long term erythropoietin therapy on the hypothalamic-pituitary-thyroid axi...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bosnian journal of basic medical sciences / Udruženje basičnih mediciniskih znanosti = Association of Basic Medical Sciences     Volume:  11     ISSN:  1840-4812     ISO Abbreviation:  Bosn J Basic Med Sci     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101200947     Medline TA:  Bosn J Basic Med Sci     Country:  Bosnia and Hercegovina    
Other Details:
Languages:  eng     Pagination:  27-32     Citation Subset:  IM    
Affiliation:
Department of Rheumatology, Health Center Kragujevac, Zmaj Jovina bb street, Kragujevac, Serbia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  HLA Association in SLE patients from Lahore-Pakistan.
Next Document:  Serum total antioxidant capacity in patients with multiple sclerosis.