| Cartilage and meniscus assessment using T1rho and T2 measurements in healthy subjects and patients with osteoarthritis. | |
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MedLine Citation:
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PMID: 20696262 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to evaluate meniscal degeneration in healthy subjects and subjects with osteoarthritis (OA) using T(1ρ) and T(2) measurements and to examine the interrelationship between cartilage and meniscus abnormalities. METHODS: Quantitative assessment of cartilage and meniscus was performed using 3T Magnetic Resonance Imaging (MRI) with a T(1ρ) and T(2) mapping technique in 19 controls and 44 OA patients. A sagittal T(2)-weighted fast spin echo (FSE) fat-saturated image was acquired for cartilage and meniscal Whole-Organ Magnetic Resonance Imaging Score (WORMS) assessment. Western Ontario and McMasters Universities Arthritis Index (WOMAC) scores were obtained to assess clinical symptoms. RESULTS: The posterior horn of the medial meniscus (PHMED) had the highest incidence of degeneration. Stratifying subjects on the basis of PHMED grade revealed that the T(1ρ) and the T(2) measurements of the PHMED and the medial tibial (MT) cartilage were higher in subjects having a meniscal tear (meniscal grade 2-4) compared to subjects with a meniscal grade of 0 or 1 (P<0.05). While not statistically significant, there was a trend for T(1ρ) and T(2) being higher in PHMED grade 1 compared to grade 0 (P=0.094, P=0.073 respectively). WOMAC scores had a stronger correlation with meniscus relaxation measures than cartilage measures. CONCLUSIONS: Magnetic Resonance (MR) T(1ρ) and T(2) measurements provide a non-invasive means of detecting and quantifying the severity of meniscal degeneration. Meniscal damage has been implicated in OA progression and is correlated with cartilage degeneration. Early detection of meniscal damage represented by elevations in meniscal relaxation measures may identify subjects at increased risk for OA. |
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Authors:
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Z A Zarins; R I Bolbos; J B Pialat; T M Link; X Li; R B Souza; S Majumdar |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-08-07 |
Journal Detail:
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Title: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society Volume: 18 ISSN: 1522-9653 ISO Abbreviation: Osteoarthr. Cartil. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-08 Completed Date: 2011-02-24 Revised Date: 2012-04-06 |
Medline Journal Info:
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Nlm Unique ID: 9305697 Medline TA: Osteoarthritis Cartilage Country: England |
Other Details:
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Languages: eng Pagination: 1408-16 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cartilage, Articular / pathology* Cross-Sectional Studies Female Humans Image Processing, Computer-Assisted / methods* Magnetic Resonance Imaging / methods* Male Menisci, Tibial / injuries, pathology* Middle Aged Osteoarthritis, Knee / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG017762-10/AG/NIA NIH HHS; R01 AR046905-10/AR/NIAMS NIH HHS; R01 AR046905-12/AR/NIAMS NIH HHS; R01 AR46905/AR/NIAMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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