| Carriage of Neisseria meningitidis and Neisseria lactamica in infants and children. | |
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MedLine Citation:
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PMID: 415097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Asymptomatic carriage of Neisseria meningitidis and Neisseria lactamica was studied in a total of 2,969 healthy infants and children in Danbury, Conn., between October 1971 and June 1975. The prevalence of N. meningitidis averaged 0.71% during the first four years of life and increased to 5.4% by 14--17 years. Rates of carriage of N. lactamica increased from 3.8% in three-month-old infants to a peak of 21.0% at 18 months and then declined to 1.8% by 14--17 years of age. Of the children who acquired N. lactamica, 66% developed fourfold or greater rises in titers of IgG antibody to groups A, B, and/or C meningococci as determined by immunofluorescence compared with only 5% of control children. Of new carriers of N. lactamica, 40% developed increased titers of bactericidal antibody to groups A, B, and/or C meningococci as compared with 7% of noncarriers. Carriage of N. lactamica may assist in the development of natural immunity to N. meningitidis by induction of cross-reactive antibodies. |
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Authors:
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R Gold; I Goldschneider; M L Lepow; T F Draper; M Randolph |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 137 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1978 Feb |
Date Detail:
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Created Date: 1978-04-26 Completed Date: 1978-04-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 112-21 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Antibodies, Bacterial Carrier State Child Child, Preschool Cross Reactions Humans Infant Nasopharynx / microbiology Neisseria / growth & development, immunology, isolation & purification* Neisseria meningitidis / growth & development, immunology, isolation & purification* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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