| Carriage of the EGF rs4444903 A>G functional polymorphism associates with disease progression in chronic HBV infection. | |
| | |
MedLine Citation:
|
PMID: 22236006 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Because epidermal growth factor (EGF) up-regulation is characteristic of the cirrhotic liver, we hypothesised that the EGF rs4444903 A > G functional polymorphism might be associated with a worse disease course in patients with chronic HBV infection. To verify this hypothesis, 170 HBV-positive patients (125 males) with a median age of 52 years were studied. Sixty-two of these patients were followed longitudinally for a median time of 21 years. Genotyping for the EGF rs4444903 A > G polymorphism was performed by the polymerase chain reaction-based restriction fragment length polymorphism assay. In the cross-sectional study, the EGF rs4444903 A > G polymorphism genotypic frequencies significantly differed between transplant patients (A/A = 20·4%, A/G = 52·3%, G/G = 27·3%) and HBsAg+ carriers (active and inactive: A/A = 35·7%, A/G = 47·6%, G/G = 16·7%, P = 0·036 for the linear trend). In the longitudinal study, the EGF rs4444903 A > G polymorphism was found to be an independent predictor of cirrhosis development (O.R. 7·73, 95% C.I. 1·21-49·5, P = 0·007). Three groups of patients were identified: A/A female homozygotes (n = 9), A/A male homozygotes (n = 13) and carriers of the G allele of either gender (n = 40). Cirrhosis did not occur among A/A females (n = 0/9), seldom occurred among A/A males (n = 2/13) and reached the highest frequency among G/* patients (n = 13/40, P = 0·026). In conclusion, the EGF rs4444903 A > G polymorphism appears to be associated with an unfavourable disease course of chronic HBV infection and cirrhosis development. This effect might be modulated, at least in part, by the gender of the patient. |
| | |
Authors:
|
S Cmet; C Fabris; G Fattovich; E Falleti; D Bitetto; A Cussigh; E Fontanini; E Fornasiere; M Pirisi; P Toniutto |
Related Documents
:
|
6701736 - Regional isolated perfusion of high risk melanoma of the extremities with imidazole car... 17922336 - Noninvasive assessment of endothelial activity in patients with peripheral arterial dis... 20557996 - Comparison of warm ischemia versus no ischemia during partial nephrectomy on a solitary... 20298946 - Chronic mesenteric ischemia: how to select patients for invasive treatment. 8756056 - A clinical sign for persistent harmful cannabis abuse?: a pilot study. 20464276 - [anemia, renal dysfunction and malnutrition associated with heart failure in patients w... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical and experimental immunology Volume: 167 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-01-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
|
Languages: eng Pagination: 296-302 Citation Subset: IM |
Copyright Information:
|
© 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology. |
Affiliation:
|
Laboratory Medicine Medical Liver Transplant Unit, Internal Medicine, Department of Medical Sciences, Clinical and Experimental, University of Udine, Udine Department of Surgical and Gastroenterological Sciences, University of Verona, Verona Department of Clinical and Experimental Medicine Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Piemonte Orientale 'A. Avogadro', Novara, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cytokine profile and induction of T helper type 17 and regulatory T cells by human peripheral mononu...
Next Document: M-ficolin levels are associated with the occurrence of severe infections in patients with haematolog...