Document Detail

Carrageenan colitis in the guinea pig: pathological changes and the importance of ascorbic acid deficiency in disease induction.
MedLine Citation:
PMID:  4091760     Owner:  NLM     Status:  MEDLINE    
In guinea pigs deprived of ascorbic acid, the oral administration of degraded E. spinosum carrageenan induced mild to moderate colitis, while E. cottonii consistently induced severe colitis. A variable degree of colitis was observed in scorbutic animals not receiving carrageenan. By contrast, in animals given large daily supplements of ascorbic acid, neither type of carrageenan consistently induced colitis and severe disease was rarely observed. The severe colitis induced by E. cottonii in scorbutic animals markedly affected the mid and distal colon and showed histological changes similar to human ulcerative colitis.
J M Langman; R Rowland; B Vernon-Roberts
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Australian journal of experimental biology and medical science     Volume:  63 ( Pt 5)     ISSN:  0004-945X     ISO Abbreviation:  Aust J Exp Biol Med Sci     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1986-03-24     Completed Date:  1986-03-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0416662     Medline TA:  Aust J Exp Biol Med Sci     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  545-53     Citation Subset:  IM    
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MeSH Terms
Ascorbic Acid Deficiency / complications*
Carrageenan / classification,  toxicity*
Colitis, Ulcerative / chemically induced*,  complications,  pathology
Guinea Pigs
Reg. No./Substance:

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