| Carprofen and buprenorphine prevent hyperalgesia in a model of inflammatory pain in cats. | |
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MedLine Citation:
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PMID: 17363018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A model of nociceptive threshold determination was developed for evaluation of NSAID analgesia in cats. In a crossover study, eight cats received carprofen (4 mg/kg), buprenorphine (0.01 mg/kg) or saline (0.3 ml) subcutaneously before intradermal kaolin injection on the antebrachium to induce mild inflammation. Pressure thresholds were measured at the injected site using blunt-ended pins advanced by manual inflation of a bladder within a bracelet. Bladder pressure was recorded as threshold (PT) at the behavioural end point. Baseline PT were recorded before kaolin injection (time 0). PT was measured at 2-10 h intervals for 52 h. PT below the lower 95% confidence interval (CI) of baseline values indicated hyperalgesia. After saline, hyperalgesia was detected from 2-6 h, 22-26 h, and at 30 and 36 h. After carprofen, PT remained within the 95% CI. After buprenorphine, PT remained within the 95% CI except at 2h. Carprofen and to some extent buprenorphine, prevented inflammatory hyperalgesia. |
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Authors:
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P M Taylor; P V M Steagall; M J Dixon; T H Ferreira; S P L Luna |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2007-03-23 |
Journal Detail:
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Title: Research in veterinary science Volume: 83 ISSN: 0034-5288 ISO Abbreviation: Res. Vet. Sci. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-09-18 Completed Date: 2007-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401300 Medline TA: Res Vet Sci Country: England |
Other Details:
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Languages: eng Pagination: 369-75 Citation Subset: IM |
Affiliation:
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Taylor Monroe, Gravel Head Farm, Downham Common, Little Downham, Ely, Cambs CB6 2TY, UK. polly@taylormonroe.co.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents, Non-Steroidal / therapeutic use Buprenorphine / therapeutic use* Carbazoles / therapeutic use* Cat Diseases / drug therapy* Cats Cross-Over Studies Female Hyperalgesia / drug therapy, veterinary* Inflammation / complications* Male Pain / complications, drug therapy, veterinary* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Carbazoles; 52263-47-5/carprofen; 52485-79-7/Buprenorphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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