Document Detail

Carprofen and buprenorphine prevent hyperalgesia in a model of inflammatory pain in cats.
MedLine Citation:
PMID:  17363018     Owner:  NLM     Status:  MEDLINE    
A model of nociceptive threshold determination was developed for evaluation of NSAID analgesia in cats. In a crossover study, eight cats received carprofen (4 mg/kg), buprenorphine (0.01 mg/kg) or saline (0.3 ml) subcutaneously before intradermal kaolin injection on the antebrachium to induce mild inflammation. Pressure thresholds were measured at the injected site using blunt-ended pins advanced by manual inflation of a bladder within a bracelet. Bladder pressure was recorded as threshold (PT) at the behavioural end point. Baseline PT were recorded before kaolin injection (time 0). PT was measured at 2-10 h intervals for 52 h. PT below the lower 95% confidence interval (CI) of baseline values indicated hyperalgesia. After saline, hyperalgesia was detected from 2-6 h, 22-26 h, and at 30 and 36 h. After carprofen, PT remained within the 95% CI. After buprenorphine, PT remained within the 95% CI except at 2h. Carprofen and to some extent buprenorphine, prevented inflammatory hyperalgesia.
P M Taylor; P V M Steagall; M J Dixon; T H Ferreira; S P L Luna
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-03-23
Journal Detail:
Title:  Research in veterinary science     Volume:  83     ISSN:  0034-5288     ISO Abbreviation:  Res. Vet. Sci.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-09-18     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  369-75     Citation Subset:  IM    
Taylor Monroe, Gravel Head Farm, Downham Common, Little Downham, Ely, Cambs CB6 2TY, UK.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Buprenorphine / therapeutic use*
Carbazoles / therapeutic use*
Cat Diseases / drug therapy*
Cross-Over Studies
Hyperalgesia / drug therapy,  veterinary*
Inflammation / complications*
Pain / complications,  drug therapy,  veterinary*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Carbazoles; 52263-47-5/carprofen; 52485-79-7/Buprenorphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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