Document Detail


Carotid plaque, stroke pathogenesis, and CRP: treatment of ischemic stroke.
MedLine Citation:
PMID:  18416997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
C-reactive protein (CRP), an inflammatory marker, has been identified as a likely predictor of the risk of a future stroke. In clinical settings, it has been consistently observed that higher concentrations of CRP are associated with larger brain infarcts and worst neurologic outcome. However, there is still controversy over the degree of risk conferred by elevated CRP concentrations. CRP, like many other hemostatic factors, is an acute-phase protein and, therefore, it is not always clear whether its association with cerebrovascular disease reflects its contribution to atherothrombosis, its acute-phase condition, or both. Whether a reduction of CRP levels could be beneficial to stroke patients remains to be clarified. More studies are needed before CRP becomes a routine part of the evaluation of stroke patients.
Authors:
Jerzy Krupinski; Marta M Turu; Mark Slevin; José Martínez-González
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current cardiology reports     Volume:  10     ISSN:  1534-3170     ISO Abbreviation:  Curr Cardiol Rep     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-04-17     Completed Date:  2008-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888969     Medline TA:  Curr Cardiol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-30     Citation Subset:  IM    
Affiliation:
Department of Neurology, Stroke Unit, Hospital Universitari de Bellvitge, Feixa Llarga s/n 08907 L'Hospitalet de Llobregat, Barcelona, Spain. krupinski@csub.scs.es
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MeSH Terms
Descriptor/Qualifier:
Antihypertensive Agents / therapeutic use
Brain Ischemia / blood,  drug therapy,  physiopathology*
C-Reactive Protein / metabolism*
Carotid Arteries / pathology*,  physiopathology
Carotid Artery Diseases / blood,  pathology*,  physiopathology
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Inflammation
Platelet Aggregation Inhibitors / therapeutic use
Risk Factors
Stroke / blood,  drug therapy,  physiopathology*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Platelet Aggregation Inhibitors; 9007-41-4/C-Reactive Protein

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