| Carotid plaque formation and serum biomarkers. | |
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MedLine Citation:
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PMID: 20627248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment of carotid artery stenosis by endarterectomy or stenting can significantly reduce stroke risk, but is also associated with surgery related mortality and morbidity. At present it is neither possible to assess whether a carotid plaque will become symptomatic or not, nor to define the time when symptoms will occur. Identification of carotid plaques which confer excess risk of neurologic events is fundamental in the selection of patients for vascular intervention. Molecular processes such as inflammation, lipid accumulation, apoptosis, proteolysis, thrombosis and angiogenesis have shown to be highly related with plaque vulnerability. Serum biomarkers reflecting these processes may distinguish unstable from stable carotid artery stenosis and thus be a powerful tool in the selection of patients for carotid surgery. Until now, no serum biomarker has qualified for regular clinical use in carotid artery disease. However, several biomarkers, especially markers of inflammatory or proteolytic activity seem to be promising in the identification of vulnerable carotid plaques. Therefore, it is anticipated that non-invasive risk assessment in carotid artery disease by determination of serum biomarker levels may play an important future role in clinical practice improving better selection criteria for vascular intervention. |
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Authors:
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Linda Hermus; Joop D Lefrandt; René A Tio; Jan-Cees Breek; Clark J Zeebregts |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-05-19 |
Journal Detail:
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Title: Atherosclerosis Volume: 213 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-25 Completed Date: 2011-03-07 Revised Date: 2011-06-22 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 21-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Surgery (Division of Vascular Surgery), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anoxia Apoptosis Biological Markers / metabolism Cardiology / methods* Carotid Arteries / pathology Carotid Stenosis / blood* Endarterectomy, Carotid / methods Humans Inflammation Lipids / chemistry Neovascularization, Pathologic Stroke / prevention & control Thrombosis / pathology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Lipids |
| Comments/Corrections | |
Erratum In:
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Atherosclerosis. 2011 May;216(1):249 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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