Document Detail

Carotid plaque formation and serum biomarkers.
MedLine Citation:
PMID:  20627248     Owner:  NLM     Status:  MEDLINE    
Treatment of carotid artery stenosis by endarterectomy or stenting can significantly reduce stroke risk, but is also associated with surgery related mortality and morbidity. At present it is neither possible to assess whether a carotid plaque will become symptomatic or not, nor to define the time when symptoms will occur. Identification of carotid plaques which confer excess risk of neurologic events is fundamental in the selection of patients for vascular intervention. Molecular processes such as inflammation, lipid accumulation, apoptosis, proteolysis, thrombosis and angiogenesis have shown to be highly related with plaque vulnerability. Serum biomarkers reflecting these processes may distinguish unstable from stable carotid artery stenosis and thus be a powerful tool in the selection of patients for carotid surgery. Until now, no serum biomarker has qualified for regular clinical use in carotid artery disease. However, several biomarkers, especially markers of inflammatory or proteolytic activity seem to be promising in the identification of vulnerable carotid plaques. Therefore, it is anticipated that non-invasive risk assessment in carotid artery disease by determination of serum biomarker levels may play an important future role in clinical practice improving better selection criteria for vascular intervention.
Linda Hermus; Joop D Lefrandt; René A Tio; Jan-Cees Breek; Clark J Zeebregts
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-05-19
Journal Detail:
Title:  Atherosclerosis     Volume:  213     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-25     Completed Date:  2011-03-07     Revised Date:  2011-06-22    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  21-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Department of Surgery (Division of Vascular Surgery), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
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MeSH Terms
Biological Markers / metabolism
Cardiology / methods*
Carotid Arteries / pathology
Carotid Stenosis / blood*
Endarterectomy, Carotid / methods
Lipids / chemistry
Neovascularization, Pathologic
Stroke / prevention & control
Thrombosis / pathology
Treatment Outcome
Reg. No./Substance:
0/Biological Markers; 0/Lipids
Erratum In:
Atherosclerosis. 2011 May;216(1):249

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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