| Carotid plaque assessment using fast 3D isotropic resolution black-blood MRI. | |
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MedLine Citation:
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PMID: 20941742 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Black-blood MRI is a promising tool for carotid atherosclerotic plaque burden assessment and compositional analysis. However, current sequences are limited by large slice thickness. Accuracy of measurement can be improved by moving to isotropic imaging but can be challenging for patient compliance due to long scan times. We present a fast isotropic high spatial resolution (0.7×0.7×0.7 mm3) three-dimensional black-blood sequence (3D-MERGE) covering the entire cervical carotid arteries within 2 min thus ensuring patient compliance and diagnostic image quality. The sequence is optimized for vessel wall imaging of the carotid bifurcation based on its signal properties. The optimized sequence is validated on patients with significant carotid plaque. Quantitative plaque morphology measurements and signal-to-noise ratio measures show that 3D-MERGE provides good blood suppression and comparable plaque burden measurements to existing MRI protocols. 3D-MERGE is a promising new tool for fast and accurate plaque burden assessment in patients with atherosclerotic plaque. |
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Authors:
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Niranjan Balu; Vasily L Yarnykh; Baocheng Chu; Jinnan Wang; Thomas Hatsukami; Chun Yuan |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-10-12 |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 65 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-21 Completed Date: 2011-06-23 Revised Date: 2012-03-07 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 627-37 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Radiology, University of Washington, Seattle, Washington 98019, USA. ninja@u.washington.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Algorithms* Anisotropy Carotid Stenosis / pathology* Female Humans Image Enhancement / methods Image Interpretation, Computer-Assisted / methods* Imaging, Three-Dimensional / methods* Magnetic Resonance Angiography / methods* Male Reproducibility of Results Sensitivity and Specificity |
| Grant Support | |
ID/Acronym/Agency:
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HL056784/HL/NHLBI NIH HHS; P01 HL072262-050002/HL/NHLBI NIH HHS; R01 HL056874-13/HL/NHLBI NIH HHS; R01 HL073401-04/HL/NHLBI NIH HHS; R01 HL088214-04/HL/NHLBI NIH HHS; R01-HL061851/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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