| Carotid intraplaque hemorrhage predicts recurrent symptoms in patients with high-grade carotid stenosis. | |
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MedLine Citation:
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PMID: 17379827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Carotid intraplaque hemorrhage (IPH), known to be associated with plaque instability, may convey a higher stroke risk. The aim of this study was to assess whether the identification of IPH by MRI predicts recurrent clinical cerebrovascular events. METHODS: Sixty-six patients with high-grade symptomatic carotid stenosis underwent MRI of the carotid arteries and were followed until carotid endarterectomy or 30 days. RESULTS: Of the 66 patients with a median follow up of 33.5 days, 44 (66.7%) were found on MRI to have ipsilateral carotid IPH. Fifteen recurrent events were associated with ipsilateral carotid IPH. Only 2 recurrent events occurred in the absence of IPH. IPH increased the risk of recurrent ischemia (hazard ratio=4.8; 95% CI=1.1 to 20.9, P<0.05). CONCLUSIONS: IPH as detected by MRI predicts recurrent cerebrovascular events in patients with symptomatic high-grade carotid stenosis. |
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Authors:
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Nishath Altaf; Shane T MacSweeney; John Gladman; Dorothee P Auer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-22 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 38 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-24 Completed Date: 2007-05-15 Revised Date: 2008-01-02 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 1633-5 Citation Subset: IM |
Affiliation:
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Department of Academic Radiology, University of Nottingham, Queen's Medical Centre, Nottingham, UK. nish.altaf@nottingham.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carotid Stenosis / complications*, surgery Female Hemorrhage / diagnosis*, etiology Humans Magnetic Resonance Imaging Male Middle Aged Predictive Value of Tests Recurrence Risk Factors Stroke / epidemiology*, etiology |
| Comments/Corrections | |
Comment In:
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Stroke. 2007 Dec;38(12):e156-7; discussion e158-161
[PMID:
17975101
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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