| Carotid intima-media thickness and paraoxonase activity in patients with ankylosing spondylitis. | |
| | |
MedLine Citation:
|
PMID: 21810380 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Purpose: The risk of atherosclerosis is increased in several rheumatological disorders, but any such risk remains unproven for ankylosing spondylitis. Since carotid intima-media thickness is an indicator of early atherosclerosis, and the paraoxonase (PON1) enzyme has antioxidant activity to prevent LDL oxidation, we aimed to identify: 1) the relationship between carotid intima-media thickness (CIMT) and serum paraoxonase (PON1) activity in ankylosing spondylitis (AS) patients; and 2) the possible differences in CIMT in AS patients versus age-matched, healthy controls. Methods: Forty-five AS patients (36.8±9.8 years, 36 males, 9 females) and 30 controls (35.9±10.2 years, 23 males, 7 females) were recruited consecutively. Serum PON1 activity and CIMT were measured. The Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Radiologic Index (BASRI) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were used to identify relationships between these clinical indices and levels of CIMT and PON1. Results: Mean CIMT was significantly increased in AS patients relative to controls (0.49±0.06 mm vs. 0.59±0.07 mm; p < 0.0001). Conversely, serum PON1 activity was decreased (199.1±60.3 U/L vs. 96.7±29 U/L; p < 0.0001). PON1 activity was negatively correlated with CIMT (r = -0.557, p = 0.0001). Disease duration was positively correlated with CIMT (r = 0.542, p = 0.0001) and negatively correlated with PON1 (r = -0.649, p = 0.0001). On multivariate analysis, disease duration and serum PON1 activity were found to be independent predictors of CIMT (R2 = 0.687, p = 0.0001). Conclusions: In conclusion, significantly increased CIMT and decreased PON1 activity suggest a relationship between atherosclerosis and AS: a relationship that is strongly correlated with disease duration. |
| | |
Authors:
|
Hasan Cece; Pelin Yazgan; Ekrem Karakas; Omer Karakas; Ahmet Demirkol; Ismail Toru; Nurten Aksoy |
Publication Detail:
|
Type: Journal Article Date: 2011-08-01 |
Journal Detail:
|
Title: Clinical and investigative medicine. Médecine clinique et experimentale Volume: 34 ISSN: 1488-2353 ISO Abbreviation: Clin Invest Med Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-08-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7804071 Medline TA: Clin Invest Med Country: Canada |
Other Details:
|
Languages: eng Pagination: E225 Citation Subset: IM |
Affiliation:
|
. hasan_cece@yahoo.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Factors associated with cumulative research funding of investigators from CIHR - a major health-rese...
Next Document: Elevated serum receptor activator of nuclear factor kappa B ligand and osteoprotegerin levels in lat...