Document Detail


Carotid intima-media thickness and arterial stiffness in preeclampsia by analysis with a radio-frequency ultrasound technique.
MedLine Citation:
PMID:  23335074     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Whether the regional elastic arteries is stiffened in preeclampsia has less been investigated. This study was aimed to characterize in vivo the carotid arterial intima-media thickness (IMT) and mechanical properties in women with preeclampsia by employing a radio-frequency ultrasound technique. METHODS: Twenty-two preeclampsia women and 28 age- and gestational-week matched (36.0 ±3.2 weeks vs. 35.8±2.4 weeks, p=0.802 ) normotensive women were included. All subjects were nulliparas. The preeclampsia women had a significantly higher arterial pressure than normotensive pregnancy (p<0.0001). All women underwent common carotid artery measurements with MylabTwice ultrasound instrument (Esaote, Italy) equipped with Automatic Quality IMT (QIMT) and Quality Arterial Stiffness (QAS) packages. Carotid IMT and arterial stiffness were evaluated before in all subjects. Follow up study was performed. RESULTS: Carotid IMT (459±95 µm vs. 351±85 µm, p=0.0001) , internal diameter (7.8±0.5 mm vs. 7.2±0.4 mm, p<0.0001), pulse wave velocity (7.1±1.7 m/s vs. 6.0±1.1 m/s, p=0.024), augmentation index (7.1±8.8% vs. -5.6±7.3%, p<0.0001) and carotid arterial wall tension (55.0±6.5 mmHg/cm vs. 38.6±4.9 mmHg/cm, p<0.0001) were remarkably greater, and the distensibility coefficient (0.020±0.009 1/kPa vs. 0.029±0.011 1/kPa, p=0.006) was significantly smaller in preeclampsia compared to normotensive pregnancy and remained after adjusting for BMI and carotid pressures. Eighteen months after parturition, carotid diameter, pressure and wall tension was still greater in women with history of preeclampsia. CONCLUSION: Carotid remodeling and arterial stiffening occur in preeclampsia and and may be partially recovered postpartum. QIMT and QAS techniques together could provide a comprehensive assessment of the carotid arterial remodeling.
Authors:
Li-Jun Yuan; Dan Xue; Yun-You Duan; Tie-Sheng Cao; Hua-Guang Yang; Ning Zhou
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 ISUOG. Published by John Wiley & Sons, Ltd.
Affiliation:
Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, China.
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