Document Detail

Carotid endarterectomy in young adults: is it a worthwhile procedure?
MedLine Citation:
PMID:  9081127     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of the study was to investigate surgical indication and long-term outcome of carotid endarterectomy (CE) in young adults.
METHODS: Between 1973 and 1990, 1693 patients underwent CE. Forty-nine patients (group T) 35 to 45 years of age who had carotid artery stenosis greater than 70%, formed the basis for the analysis. They were compared with two additional groups of patients older than 45 years of age selected from the entire series. Group 2 was randomly chosen to determine differences in risk factors, associated diseases, operative indications, preoperative findings, and outcome. Group 3 was matched with patients in group 1 for sex, risk factors, associated diseases, preoperative findings, and operative indications to assess the importance of age in determining the short- and long-term outcome of CE.
RESULTS: Postoperative mortality, cerebrovascular accidents, and cardiac complications in patients of group 1 (2%, 2%, and 2%, respectively) were similar to those of the other groups (p = NS). During the follow-up (76.7 +/- 3.6 months; range, 1 to 120 months) the incidence of strokes and transient ischemic attacks in group 1 was lower than in group 2 (p < 0.05) but similar to group 3 (p = NS). Ten-year disease-free intervals were 75.7%, 58.7%, and 77.6%, respectively, for groups 1, 2, and 3. Mortality rate unrelated to cerebrovascular disease was similar between group 1 and group 3 (p = NS) but was higher in group 1 than in group 2 (p < 0.02). Ten-year survival rates were 46.1%, 71.7%, and 55.5%, respectively, for groups 1, 2, and 3.
CONCLUSIONS: CE in patients younger than 45 years of age is a safe procedure with low operative risks and good disease-free intervals. However, life expectancy is poor because of the high incidence of deaths resulting from complications of atherosclerosis.
A Mingoli; P Sapienza; R J Feldhaus; L di Marzo; G Sgarzini; C Burchi; C Modini; A Cavallaro
Related Documents :
16729227 - Complications and follow-up after unprotected carotid artery stenting.
1785027 - Early prognosis of stroke outcome by means of katz index of activities of daily living.
1823637 - Natural history of islet cell antibodies during the clinical period of type 1 diabetes....
16193247 - Stroke and transient ischaemic attack in 18 neurology departments from two italian regi...
11261747 - Switching from pergolide to pramipexole in patients with parkinson's disease.
21481857 - The impact of suboptimal bowel preparation on adenoma miss rates and the factors associ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  25     ISSN:  0741-5214     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-04-16     Completed Date:  1997-04-16     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  464-70     Citation Subset:  IM    
Creighton University, Omaha, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Factors
Carotid Stenosis / complications,  mortality,  surgery
Cerebrovascular Disorders / etiology
Disease-Free Survival
Endarterectomy, Carotid* / adverse effects,  mortality
Follow-Up Studies
Ischemic Attack, Transient / etiology
Middle Aged
Postoperative Complications
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Antisense oligonucleotide to proto-oncogene c-myb inhibits the formation of intimal hyperplasia in e...
Next Document:  Urokinase does not upregulate the vascular endothelial cell-mediated inflammatory response.