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Carotid cross-sectional wall area is significantly associated with serum leptin levels, independent of body mass index: the SABPA study.
MedLine Citation:
PMID:  22932876     Owner:  NLM     Status:  Publisher    
Hypertension and obesity are serious health burdens in sub-Saharan Africa. Urbanized Africans seem to be more susceptible to the development of these diseases than Caucasians. Current research suggests that leptin may be an important contributor to the development of hypertension and atherosclerosis. The aim of this study was to investigate leptin levels and their associations with cardiovascular function in urbanized Africans and Caucasians. Serum leptin, ambulatory blood pressure and carotid intima-media thickness were measured, and the cross-sectional wall area (CSWA) was calculated. The results showed that Africans had higher leptin levels (P<0.001), ambulatory blood pressure (P<0.001), carotid intima-media thickness (P<0.01) and CSWA (P<0.01) than Caucasians. As we found no interaction between ethnicity and gender for the association between leptin and the cardiovascular variables, we focused mainly on the total group of Africans and Caucasians. In single, partial and multiple regression analyses, positive associations of ambulatory systolic blood pressure (β=0.256; P<0.001), diastolic blood pressure (β=0.143; P=0.012), pulse pressure (β=0.327; P<0.001) and CSWA (β=0.107; P=0.038) with leptin were observed. Even after adjusting for body mass index (BMI), the association between CSWA (β=0.107; P=0.038) and leptin remained. Our findings therefore suggest that leptin may contribute to the development of atherosclerosis, independent of BMI.Hypertension Research advance online publication, 30 August 2012; doi:10.1038/hr.2012.130.
Chiné Pieterse; Alta E Schutte; Carina Mels; Wayne Smith; Rudolph Schutte
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-30
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  -     ISSN:  1348-4214     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Hypertension in Africa Research Team (HART), School for Physiology, Nutrition, and Consumer Sciences, North-West University, Potchefstroom, South Africa.
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