| Carotid chemoreceptor modulation of regional blood flow distribution during exercise in health and chronic heart failure. | |
| | |
MedLine Citation:
|
PMID: 17431189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Previous work has shown sensitization of carotid chemoreceptor (CC) responsiveness during exercise as well as in chronic heart failure (CHF). Accordingly, we hypothesized that the CCs contribute to the sympathetic restraint of skeletal muscle blood flow during exercise and CHF. We examined the effect of transient CC inhibition on total (Con(T)) and hindlimb (Con(L)) conductance, and blood pressure at rest and during exercise (2.5 miles per hour, 5% grade) in chronically instrumented dogs. Via a carotid arterial catheter, CCs were inhibited using dopamine (5 to 10 microg/kg) or hyperoxic lactated Ringer's solution. Although vasodilation did not occur with CC inhibition in resting healthy dogs, CC inhibition during exercise caused an immediate vasodilatory response (increase in Con(T) and Con(L) and decrease in blood pressure). When comparing the peak Con(L) response from CC inhibition versus alpha-adrenergic blockade (phentolamine), we found that the CCs accounted for approximately one-third of the total sympathetic restraint during exercise. CHF was then induced by chronic rapid cardiac pacing and characterized by impaired cardiac function, enhanced chemosensitivity, and greater sympathetic restraint at rest and during exercise. In contrast to healthy dogs, CC inhibition in resting CHF dogs produced vasodilation, whereas a similar vasodilatory response was observed during exercise in CHF as compared with healthy dogs. The vasodilation following CC inhibition during exercise and in CHF was abolished with alpha-adrenergic blockade and was absent in healthy exercising animals after carotid body denervation. These results establish an important role for the CCs in cardiovascular control in the healthy animal during exercise and in the CHF animal both at rest and during exercise. |
| | |
Authors:
|
Michael K Stickland; Jordan D Miller; Curtis A Smith; Jerome A Dempsey |
Related Documents
:
|
6949469 - Hydralazine in chronic chf. 16338939 - Enhanced prognostic value from cardiopulmonary exercise testing in chronic heart failur... 9799209 - Skeletal muscle metabolism limits exercise capacity in patients with chronic heart fail... 14689369 - Impaired neuronal and vascular responses to angiotensin ii in a rabbit congestive heart... 19008089 - Does exercise have deleterious consequences for the lungs of patients with chronic hear... 11896019 - Exercise training normalizes altered calcium-handling proteins during development of he... 16282579 - The effects of plyometric versus dynamic stabilization and balance training on lower ex... 9628229 - Ventilatory response to asphyxia in conscious rats: effect of ambient and body temperat... 16802769 - The role of chemokines in exercise-induced bronchoconstriction in asthma. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-04-12 |
Journal Detail:
|
Title: Circulation research Volume: 100 ISSN: 1524-4571 ISO Abbreviation: Circ. Res. Publication Date: 2007 May |
Date Detail:
|
Created Date: 2007-05-14 Completed Date: 2007-05-29 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0047103 Medline TA: Circ Res Country: United States |
Other Details:
|
Languages: eng Pagination: 1371-8 Citation Subset: IM |
Affiliation:
|
John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison, WI, USA. Michael.Stickland@ualberta.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects Carotid Body / physiology* Dogs Dopamine / pharmacology Female Heart Failure / physiopathology* Hindlimb / blood supply Muscle, Skeletal / blood supply* Phentolamine / pharmacology Physical Conditioning, Animal* Regional Blood Flow / drug effects Sympathetic Nervous System / physiology Vasoconstriction |
| Grant Support | |
ID/Acronym/Agency:
|
R01-HL015469/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
50-60-2/Phentolamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only...
Next Document: Mechanisms of TGF-beta1-induced intimal growth: plasminogen-independent activities of plasminogen ac...