Document Detail


Carotid body excision significantly changes ventilatory control in awake rats.
MedLine Citation:
PMID:  3372424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We determined the effects of carotid body excision (CBX) on eupneic ventilation and the ventilatory responses to acute hypoxia, hyperoxia, and chronic hypoxia in unanesthetized rats. Arterial PCO2 (PaCO2) and calculated minute alveolar ventilation to minute metabolic CO2 production (VA/VCO2) ratio were used to determine the ventilatory responses. The effects of CBX and sham operation were compared with intact controls (PaCO2 = 40.0 +/- 0.1 Torr, mean +/- 95% confidence limits, and VA/VCO2 = 21.6 +/- 0.1). CBX rats showed 1) chronic hypoventilation with respiratory acidosis, which was maintained for at least 75 days after surgery (PaCO2 = 48.4 +/- 1.1 Torr and VA/VCO2 = 17.9 +/- 0.4), 2) hyperventilation in response to acute hyperoxia vs. hypoventilation in intact rats, 3) an attenuated increase in VA/VCO2 in acute hypoxemia (arterial PO2 approximately equal to 49 Torr), which was 31% of the 8.7 +/- 0.3 increase in VA/VCO2 observed in control rats, 4) no ventilatory acclimatization between 1 and 24 h hypoxia, whereas intact rats had a further 7.5 +/- 1.5 increase in VA/VCO2, 5) a decreased PaCO2 upon acute restoration of normoxia after 24 h hypoxia in contrast to an increased PaCO2 in controls. We conclude that in rats carotid body chemoreceptors are essential to maintain normal eupneic ventilation and to the process of ventilatory acclimatization to chronic hypoxia.
Authors:
E B Olson; E H Vidruk; J A Dempsey
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  64     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-06-27     Completed Date:  1988-06-27     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  666-71     Citation Subset:  IM    
Affiliation:
John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, School of Medicine, University of Wisconsin, Madison 53705.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Anoxia / physiopathology*
Carotid Body / physiopathology*
Chronic Disease
Male
Rats
Rats, Inbred Strains
Respiration*
Grant Support
ID/Acronym/Agency:
HL-00780/HL/NHLBI NIH HHS; HL-29043/HL/NHLBI NIH HHS; HL-31430/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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