Document Detail

Carotid body denervation in dogs: eupnea and the ventilatory response to hyperoxic hypercapnia.
MedLine Citation:
PMID:  11408448     Owner:  NLM     Status:  MEDLINE    
We assessed the time course of changes in eupneic arterial PCO(2) (Pa(CO(2))) and the ventilatory response to hyperoxic rebreathing after removal of the carotid bodies (CBX) in awake female dogs. Elimination of the ventilatory response to bolus intravenous injections of NaCN was used to confirm CBX status on each day of data collection. Relative to eupneic control (Pa(CO(2)) = 40 +/- 3 Torr), all seven dogs hypoventilated after CBX, reaching a maximum Pa(CO(2)) of 53 +/- 6 Torr by day 3 post-CBX. There was no significant recovery of eupneic Pa(CO(2)) over the ensuing 18 days. Relative to control, the hyperoxic CO(2) ventilatory (change in inspired minute ventilation/change in end-tidal PCO(2)) and tidal volume (change in tidal volume/ change in end-tidal PCO(2)) response slopes were decreased 40 +/- 15 and 35 +/- 20% by day 2 post-CBX. There was no recovery in the ventilatory or tidal volume response slopes to hyperoxic hypercapnia over the ensuing 19 days. We conclude that 1) the carotid bodies contribute approximately 40% of the eupneic drive to breathe and the ventilatory response to hyperoxic hypercapnia and 2) there is no recovery in the eupneic drive to breathe or the ventilatory response to hyperoxic hypercapnia after removal of the carotid chemoreceptors, indicating a lack of central or aortic chemoreceptor plasticity in the adult dog after CBX.
J R Rodman; A K Curran; K S Henderson; J A Dempsey; C A Smith
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  91     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-06-15     Completed Date:  2001-08-16     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  328-35     Citation Subset:  IM    
The John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin School of Medicine, Madison, Wisconsin 53705, USA.
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MeSH Terms
Blood Pressure
Carotid Body / physiology*
Chemoreceptor Cells / physiology
Diaphragm / physiology,  physiopathology
Gases / blood
Hypercapnia / physiopathology*
Hyperoxia / physiopathology*
Reference Values
Tidal Volume
Grant Support
Reg. No./Substance:
Erratum In:
J Appl Physiol 2001 Nov;91(5):following table of contents

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