Document Detail


Carotid body and cardiorespiratory alterations in intermittent hypoxia: the oxidative link.
MedLine Citation:
PMID:  19996187     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intermittent hypoxia, a feature of obstructive sleep apnoea, potentiates ventilatory hypoxic responses, alters heart rate variability and produces hypertension, partially owing to an enhanced carotid body responsiveness to hypoxia. Since oxidative stress is a potential mediator of both chemosensory and cardiorespiratory alterations, we hypothesised that an antioxidant treatment may prevent these alterations. Accordingly, we studied the effects of ascorbic acid (1.25 g.L(-1) drinking water) on plasma lipid peroxidation, nitrotyrosine and inducible nitric oxide synthase (iNOS) immunoreactivity in the carotid body, ventilatory and carotid chemosensory responses to acute hypoxia, heart rate variability and arterial blood pressure in male Sprague-Dawley rats exposed to 5% O(2); 12 episodes.h(-1); 8 h.day(-1) or sham condition for 21 days. Intermittent hypoxia increased plasma lipid peroxidation, nitrotyrosine and iNOS expression in the carotid body, enhanced carotid chemosensory and ventilatory hypoxic responses, modified heart rate variability and produced hypertension. Ascorbic acid prevented the increased plasma lipid peroxidation and nitrotyrosine formation within the carotid body, and the enhanced carotid chemosensory and ventilatory responses to hypoxia, as well as heart rate variability alterations and hypertension. The present results support an essential role for oxidative stress in the generation of carotid body chemosensory potentiation and systemic cardiorespiratory alterations induced by intermittent hypoxia.
Authors:
R Del Rio; E A Moya; R Iturriaga
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Publication Detail:
Type:  Journal Article     Date:  2009-12-08
Journal Detail:
Title:  The European respiratory journal     Volume:  36     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-02     Completed Date:  2010-10-21     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  143-50     Citation Subset:  IM    
Affiliation:
Laboratorio de Neurobiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Casilla 114-D Santiago, Chile.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / etiology,  prevention & control*
Antioxidants / therapeutic use*
Ascorbic Acid / administration & dosage,  therapeutic use*
Carotid Body / drug effects*,  physiopathology
Chemoreceptor Cells / metabolism,  physiology
Heart Rate / drug effects,  physiology
Hypertension / drug therapy,  metabolism,  physiopathology
Lipid Peroxidation
Lipids / blood
Male
Malondialdehyde / analysis
Nitric Oxide Synthase Type II / analysis
Nitrosamines / analysis
Oxidative Stress / drug effects,  physiology
Pulmonary Ventilation / drug effects,  physiology
Rats
Sleep Apnea, Obstructive / complications*
Tyrosine / analogs & derivatives,  analysis
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Lipids; 0/Nitrosamines; 3604-79-3/3-nitrotyrosine; 50-81-7/Ascorbic Acid; 542-78-9/Malondialdehyde; 55520-40-6/Tyrosine; EC 1.14.13.39/Nitric Oxide Synthase Type II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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