| Carotid baroreflex control of leg vasculature in exercising and non-exercising skeletal muscle in humans. | |
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MedLine Citation:
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PMID: 15388778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carotid baroreflex (CBR) function was examined in five men and three women (25 +/- 1 years) using the variable-pressure neck collar technique at rest and during dynamic, one-legged knee extension exercise at 7 W and 25 W. The CBR exhibited control of leg vascular conductance (LVC) at rest and during exercise in both an exercising leg (EL) and a non-exercising leg (NEL) across a wide range of pressures from +40 Torr neck pressure (NP) to -80 Torr neck suction (NS). Specifically, increases in LVC (% change) in response to NS were no different across -20 to -80 Torr in either EL or NEL compared to rest, P > 0.05. However, CBR-mediated decreases in percentage LVC in response to NP were attenuated in EL at both 7 W (16 +/- 1%) and 25 W (12 +/- 1%) compared to rest (40 +/- 3%; P < 0.05) as well as compared to responses in the NEL (36 +/- 6% at 7 W and 36 +/- 7% at 25 W; P < 0.05). This decrease in vascular responsiveness in EL was associated with a reduction in the gain of the percentage muscle sympathetic nerve activity (%MSNA)-%LVC relationship compared to rest (P < 0.05). Collectively, these data indicate that, despite a clear attenuation of the vascular response to MSNA in the exercising leg, CBR-mediated changes in mean arterial pressure were no different between rest and exercise. |
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Authors:
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David Melvin Keller; Paul J Fadel; Shigehiko Ogoh; Robert Matthew Brothers; Megan Hawkins; Al Olivencia-Yurvati; Peter B Raven |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2004-09-23 |
Journal Detail:
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Title: The Journal of physiology Volume: 561 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-11-19 Completed Date: 2005-04-06 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
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Languages: eng Pagination: 283-93 Citation Subset: IM |
Affiliation:
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University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA. davidkeller@texashealth.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Baroreflex / physiology* Blood Pressure / physiology Carotid Body / physiology* Exercise / physiology* Female Humans Knee / physiology Leg / blood supply, physiology Male Muscle, Skeletal / blood supply*, physiology* Rest / physiology Sympathetic Nervous System / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-045547/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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