Document Detail


Carotid baroreceptor-muscle sympathetic relation in humans.
MedLine Citation:
PMID:  3425769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to define the relation between carotid distending pressure and muscle sympathetic activity in humans. Carotid baroreceptors of nine healthy subjects were compressed or stretched for 5 s with graded neck pressure or suction (+40 to -65 mmHg), and muscle sympathetic nerve activity was recorded. The results delineate several features of human baroreflex function. First, the carotid-muscle sympathetic relation is well described by an inverse sigmoid function. Second, a linear relation exists between carotid distending pressure and sympathetic outflow over a range of approximately 25 mmHg. Third, sympathetic responses to changes of carotid pressures are asymmetric; increases of sympathetic activity during carotid compression are much greater than reductions of sympathetic activity during carotid stretch. Fourth, at rest, normal subjects operate near the threshold level for sympathetic excitation. Thus the carotid-muscle sympathetic baroreflex is poised to oppose reductions more effectively than elevations of arterial pressure, and the range of pressures over which the reflex is active is wider than thought hitherto.
Authors:
R F Rea; D L Eckberg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  253     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-01-28     Completed Date:  1988-01-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R929-34     Citation Subset:  IM; S    
Affiliation:
Department of Medicine, Veterans Administration Medical Center, Richmond, Virginia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Carotid Arteries / innervation*
Female
Humans
Male
Neck
Pressoreceptors / physiology*
Pressure
Sympathetic Nervous System / physiology*
Grant Support
ID/Acronym/Agency:
R01-HL-22296/HL/NHLBI NIH HHS; T32-HL-07580/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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