Document Detail

Carotid atherosclerosis and the risk factors in early postmenopausal Chinese women.
MedLine Citation:
PMID:  19443144     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To describe the distribution of intima-media thickness (IMT) and the prevalence of plaque by carotid segments, walls and sides, and to examine their associated risk factors in asymptomatic, early postmenopausal Chinese women in Hong Kong. METHODS: Between 2002 and 2004, the study recruited 518 postmenopausal women aged 50-64 years. They were examined by B-mode ultrasound to measure the IMT and the prevalence of plaque at the near and far walls of common carotid (CCA), bifurcation (bulb), and internal carotid (ICA) of both the left and right carotid arteries. Blood pressures, obesity indices, lipids and glucose levels, sociodemographic, medical and lifestyle factors were also obtained. RESULTS: The mean IMT was 0.76+/-0.12 mm (range: 0.53-1.33 mm). IMT was significantly thicker on the far wall than on the near wall and differed among segments (being thickest at the bulb and the narrowest at the ICA). 21.8% had at least one plaque in the carotid artery with most of the plaque found at the bulb area. Systolic blood pressure had statistically significant relationship with IMT that were fairly homogeneous among different segments. Lipids were associated with the CCA and bulb IMT, but not the ICA IMT. Diabetes predicted only CCA IMT. Older age, higher waist-hip-ratio and low-density lipoprotein cholesterol were significant predictors of plaques at all sites combined. CONCLUSIONS: We described the distribution of IMT and the prevalence of plaque in asymptomatic, early postmenopausal Chinese women. Associations of risk factors with IMT of different arterial segments were also observed.
Ruby H Y Yu; Suzanne C Ho; Stella S Y Ho; Sophie S G Chan; Jean L F Woo; A T Ahuja
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Publication Detail:
Type:  Journal Article     Date:  2009-05-13
Journal Detail:
Title:  Maturitas     Volume:  63     ISSN:  1873-4111     ISO Abbreviation:  Maturitas     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-08     Completed Date:  2009-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7807333     Medline TA:  Maturitas     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  233-9     Citation Subset:  IM    
Department of Community and Family Medicine, The Chinese University of Hong Kong, Hong Kong.
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MeSH Terms
Age Factors
Analysis of Variance
Blood Pressure
Carotid Arteries / pathology*,  ultrasonography
Carotid Artery Diseases / ethnology*,  etiology,  ultrasonography
China / ethnology
Cholesterol, LDL / blood
Diabetes Complications / ethnology,  ultrasonography
Hong Kong / epidemiology
Hypertension / complications*
Linear Models
Lipids / blood*
Logistic Models
Middle Aged
Risk Factors
Tunica Intima / pathology,  ultrasonography
Tunica Media / pathology,  ultrasonography
Waist-Hip Ratio
Reg. No./Substance:
0/Cholesterol, LDL; 0/Lipids

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