Document Detail

Carotid atherosclerosis and coronary heart disease in the metabolic syndrome: prospective data from the Bruneck study.
MedLine Citation:
PMID:  12663606     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The present study aimed at prospectively evaluating carotid atherosclerosis and coronary heart disease (CHD) in subjects with the metabolic syndrome. RESEARCH DESIGN AND METHODS: Within a prospective population-based survey examining 888 subjects aged 40-79 years, 303 subjects were identified as fulfilling World Health Organization (WHO) criteria and 158 as fulfilling the National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATP)-III criteria for diagnosing the metabolic syndrome. The 5-year change in carotid status, as assessed by echo-duplex scanning, and incident fatal and nonfatal CHD, as assessed by medical history and death certificates, were compared in subjects with the metabolic syndrome and in the rest of the sample (control subjects). RESULTS: Compared with the control subjects, subjects with the metabolic syndrome by WHO criteria had an increased 5-year incidence and progression of carotid atherosclerosis: 51 vs. 35% developed new plaques (P = 0.021) and 34 vs. 19% developed carotid stenosis >40% (P = 0.002) after adjusting for several confounders. Subjects with the metabolic syndrome by these criteria also had an increased incidence of CHD during follow-up: 8 vs. 3% in control subjects (P = 0.012). Similar results were found when the NCEP-ATPIII criteria were used. CONCLUSIONS: Subjects with the metabolic syndrome are at increased risk for both progressive carotid atherosclerosis and CHD.
Enzo Bonora; Stefan Kiechl; Johann Willeit; Friedrich Oberhollenzer; Georg Egger; Riccardo C Bonadonna; Michele Muggeo;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes care     Volume:  26     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-28     Completed Date:  2003-10-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1251-7     Citation Subset:  IM    
Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy.
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MeSH Terms
Arteriosclerosis / epidemiology*,  prevention & control
Carotid Stenosis / epidemiology*
Coronary Artery Disease / etiology*
Health Surveys
Insulin Resistance
Italy / epidemiology
Metabolic Syndrome X / complications*
Middle Aged
Prospective Studies
Risk Factors

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