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Carotid atheromatous plaques' instability. Practical implication of morphologic assessment.
MedLine Citation:
PMID:  22773462     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The only method giving the possibility of a thorough assessment of plaques instability, is a histologic examination. Three plaques categories were distinguished: unstable, potentially unstable and stable. The distribution of particular types of plaques was similar in symptomatic and asymptomatic patients. Over three quarters of lesions which could correspond to stable plaques in a macroscopic assessment, microscopically fulfilled the criteria for unstable or potentially unstable ones (the number of confirmed stable lesions vs the number of unconfirmed ones, 13 vs. 51 respectively, p < 0.0001). In a microscopic assessment made for all the plaques altogether, 52 plaques (58.4%) were considered unstable; 18 (20.2%) fulfilled the criteria for potentially unstable ones. The remaining 19 plaques (21.4%) were classified as plaques of stable structure. Unstable plaques constituted a significant majority (unstable vs potentially unstable and unstable vs. stable, p = 0.0006 and p = 0.0008 respectively). Due to the fact that majority of carotid atheromatous plaques appear to be unstable or potentially unstable because of the inflammation and related mechanisms, the role of the inflammatory-immunologic component of atherosclerosis should be used in prophylaxis of stroke and the new therapeutic concepts worked out.
Authors:
Marta Masztalewicz; Przemysław Nowacki; Anna Bajer-Czajkowska; Katarzyna Kotfis; Jowita Biernawska; Maciej Zukowski; Piotr Gutowski
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences     Volume:  50     ISSN:  1509-572X     ISO Abbreviation:  Folia Neuropathol     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9437431     Medline TA:  Folia Neuropathol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  159-65     Citation Subset:  IM    
Affiliation:
Marta Masztalewicz, The Department of Neurology, Pomeranian Medical University, Unii Lubelskiej 1, 71-252 Szczecin, Poland, e-mail: nowiczontko@poczta.onet.pl.
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