Document Detail

Carotid artery wall thickness and ischemic symptoms: evaluation using multi-detector-row CT angiography.
MedLine Citation:
PMID:  18404269     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine if carotid artery wall thickness (CAWT) studied by using multi-detector-row CT angiography (MDCTA) can be considered an effective parameter predictive of increased risk of stroke. A total of 217 patients were retrospectively studied by using MDCTA. In all patients CAWT was measured with an internal digital caliper. Continuous data were described as the mean value +/- standard deviation (SD), and they were compared with Student's t-test. Scatter plots to determine interobserver agreement were performed, and correlation coefficient was calculated with Pearson statistics. A P value <0.05 was considered to mean statistical significance. Measurements of the distal common CAWT ranged from 0.5 to 1.6 mm. In the patient group without stroke, average CAWT was 0.82 mm (0.22 SD), whereas in patient group with stroke it was 1.096 mm (0.21 SD). CAWT in patients without stroke showed statistical difference (P < 0.0001) when compared to patients with stroke. By using a threshold of 1 mm, an important statistical association between thick CAWT and stroke was found (P < 0.0001). In fact, patients with > or = 1 mm CAWT had stroke with an odds ratio of 8.16 when compared with patients with <1 mm CAWT. Resulting data suggested that an increased CAWT is an indicator for risk of stroke. This parameter should be considered in addition to other well-known risk factors such as diabetes, hypertension, smoking, and dyslipidemia.
Luca Saba; Roberto Sanfilippo; Luigi Pascalis; Roberto Montisci; Giancarlo Caddeo; Giorgio Mallarini
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2008-04-11
Journal Detail:
Title:  European radiology     Volume:  18     ISSN:  0938-7994     ISO Abbreviation:  Eur Radiol     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-05     Completed Date:  2009-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1962-71     Citation Subset:  IM    
Department of Radiology, Azienda Ospedaliero Universitaria Polo di Monserrato, s.s. 554 Monserrato, Cagliari, 09045, Italy.
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MeSH Terms
Aged, 80 and over
Brain Ischemia / epidemiology*,  radiography*
Carotid Arteries / radiography*
Cerebral Angiography / statistics & numerical data*
Italy / epidemiology
Middle Aged
Radiographic Image Interpretation, Computer-Assisted / methods
Reproducibility of Results
Risk Assessment / methods
Risk Factors
Sensitivity and Specificity
Stroke / epidemiology*,  radiography*
Tomography, X-Ray Computed / statistics & numerical data*

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