Document Detail

Carotid artery stiffness is not related to endothelial function in young healthy subjects.
MedLine Citation:
PMID:  22014538     Owner:  NLM     Status:  Publisher    
INTRODUCTION: Carotid artery stiffness, an important determinant of arterial baroreflex sensitivity, varies considerably in healthy individuals, the source of which variability is not known. Tonic relaxant influence of the endothelium on vascular smooth muscle, reducing stiffness of the vessel wall, has been established in muscular conduit arteries. It is not known to what extent stiffness of the elastic carotid artery is under endothelial control. SUBJECTS AND METHODS: Seventy-one healthy male volunteers were studied. Endothelial function was assessed by brachial artery flow mediated dilatation (FMD) normalized by diastolic shear rate (SRd). Carotid artery elastic parameters were determined by echo wall-tracking and tonometry. Systemic arterial stiffness was assessed by carotid-femoral pulse wave velocity (PWV). RESULTS: In univariate analysis carotid artery elastic parameters were related to BMI and systolic blood pressure, but were not related to any of endothelial function parameters. As expected, PWV was related inversely to nFMD. No relation was found between vascular stiffness parameters and endothelium-independent dilation (EID). CONCLUSION: Carotid artery elasticity in health is not related to conduit artery FMD, suggesting that endothelial influence on baroreceptor activity is not exerted through changes in barosensory wall elasticity.
Tamas Horvath; Alexandra Pinter; Mark Kollai
Related Documents :
16917988 - Sinolith in the ethmoid sinus.
12917128 - Retrograde flow in the left inferior petrosal sinus and blood steal of the cavernous si...
22116948 - Cervical carotid artery dissection is associated with styloid process length.
6547168 - Bacterial aneurysms of the intracavernous carotid artery.
11502668 - Bleomycin-induced pneumonitis.
18802378 - Acute kidney injury: new concepts. hepatorenal syndrome: the role of vasopressors.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-17
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  -     ISSN:  1872-7484     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Diet quality, physical activity, body weight and health-related quality of life among grade 5 studen...
Next Document:  Exploring autonomic nervous system dysfunction in patients with cancer cachexia: a pilot study.