Document Detail

Carotid artery stenting: clinical trials and registry data.
MedLine Citation:
PMID:  20826291     Owner:  NLM     Status:  MEDLINE    
Despite the lack of Level I evidence, carotid artery stenting (CAS) has emerged as an alternative to carotid endarterectomy (CEA). Furthermore, CAS has been met with considerable enthusiasm due to its minimally invasive nature and potential application to high-risk patient populations. Several investigations including multicenter registries and randomized controlled trials have been established and are currently underway in an effort to evaluate the noninferiority and efficacy of CAS as compared to CEA. To date, no trial has definitively shown equivalence of CAS to CEA for the treatment of carotid stenosis and consensus recommendations for use of CAS remain very restricted. Nevertheless, the existing data have provided useful information with respect to differential outcomes in subgroups, including symptom status, age, gender, and high-risk patient populations. Until the noninferiority of CAS is clearly demonstrated in a randomized controlled setting, CEA remains the gold standard for treatment of carotid stenosis and use of CAS must be carefully considered on an individual patient basis.
Nina M Bowens; Ronald M Fairman
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in vascular surgery     Volume:  23     ISSN:  1558-4518     ISO Abbreviation:  Semin Vasc Surg     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-09     Completed Date:  2010-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809602     Medline TA:  Semin Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  148-55     Citation Subset:  IM    
Copyright Information:
(c) 2010 Elsevier Inc. All rights reserved.
Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
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MeSH Terms
Angioplasty / adverse effects,  instrumentation*
Carotid Stenosis / surgery,  therapy*
Endarterectomy, Carotid* / adverse effects
Evidence-Based Medicine*
Multicenter Studies as Topic
Patient Selection
Practice Guidelines as Topic
Randomized Controlled Trials as Topic*
Research Design
Risk Assessment
Risk Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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