| Carotid artery stenting: analysis of a 12-year single-center experience. | |
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MedLine Citation:
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PMID: 23210872 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Purpose: To analyze a 12-year experience performing carotid artery stenting (CAS) with cerebral protection. Methods: In accord with NASCET criteria, 672 patients underwent CAS at our hospital between November 1999 and September 2011 for de novo or postsurgical restenosis; among these, 636 patients (474 men; mean age 68±6.8 years, range 63-85) had a minimum 6-month follow-up, which qualified them for this analysis. The majority of patients (381, 59.9%) were symptomatic; 47 patients had staged bilateral CAS procedures (total of 683 procedures). A cerebral protection device was used in 94.7%. Patients underwent duplex ultrasound and clinical evaluation during follow-up. Neurological adverse events were correlated with plaque morphology, patient age >80 years, learning curve, and spasm. Results: Technical success was achieved in all cases. Neurological events [3 (0.4%) major strokes, 8 (1.2%) minor strokes, and 11 (1.6%) transient ischemia attacks] occurred in 22 (3.2%) of the 683 cases within 30 days of the procedure (no events in follow-up). These involved 5 (2.0%) of the 255 asymptomatic patients and 17 (4.5%) of the 381 symptomatic patients (p=0.001). Neurological events proved to be higher in patients >80 years (6.4% vs. 2.7% of patients <80 years, p<0.05) and in those with complex plaque morphology (6.1% vs. 1.0% in stable plaques, p<0.001). After a mean follow-up of 76±32.4 months, 478 (70%) patients were alive, with a 30-day mortality of 1.9% (none due to stroke). In-stent stenosis occurred in 9 (1.3%) stents and was resolved with angioplasty or re-stenting. The primary patency rate was 98.7%. Conclusion: CAS is a valid technique for the treatment of carotid occlusive disease, with a very low rate of in-stent stenosis. Neurological complications were correlated with complex plaque morphology, which makes accurate pretreatment evaluation of the lesion mandatory if good CAS outcomes are to be achieved. |
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Authors:
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Fabrizio Fanelli; Emanuele Boatta; Alessandro Cannavale; Mario Corona; Pierleone Lucatelli; Andrea Wlderk; Carlo Cirelli; Filippo M Salvatori |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists Volume: 19 ISSN: 1545-1550 ISO Abbreviation: J. Endovasc. Ther. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100896915 Medline TA: J Endovasc Ther Country: United States |
Other Details:
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Languages: eng Pagination: 749-56 Citation Subset: IM |
Affiliation:
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Vascular and Interventional Radiology Unit, Department of Radiological Sciences, "Sapienza" University of Rome, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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