| Carotid artery stenosis: accuracy of noninvasive tests--individual patient data meta-analysis. | |
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MedLine Citation:
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PMID: 19276319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To find clinically relevant estimates of the accuracy of noninvasive imaging-Doppler ultrasonography (US), computed tomographic (CT) angiography, magnetic resonance (MR) angiography, and contrast material-enhanced MR angiography-in diagnosing both severe and moderate symptomatic carotid artery stenosis; to ascertain the effect of prespecified clinical factors and clinical setting on diagnostic accuracy; and to estimate the probability of agreement between two noninvasive tests. MATERIALS AND METHODS: Original principal investigators obtained ethics approval for each data set. All data were anonymized. Individual patient data sets (IPDs) for noninvasive imaging tests were used to determine sensitivity, specificity, and agreement between the tests for symptomatic carotid artery stenosis; to compare ipsilateral with contralateral arteries; to compare IPDs with literature estimates; to compare routine audit and research data; and to determine the effect of age and sex on sensitivity and specificity. RESULTS: Contrast-enhanced MR angiography was the most accurate (sensitivity, 0.85 [30 of 35]; 95% confidence interval [CI]: 0.69, 0.93; and specificity, 0.85 [67 of 78]; 95% CI: 0.76, 0.92) for 70%-99% symptomatic stenosis. Sensitivity for a 50%-69% stenosis was poor, although data were limited. Sensitivity and specificity were generally lower in the ipsilateral than in the contralateral artery. IPD estimates were lower than literature values. Results of comparison of research with audit-derived data were inconclusive. Neither age nor sex affected accuracy. Agreement was better between two Doppler US tests and between two contrast-enhanced MR angiographic tests than it was between Doppler US and contrast-enhanced MR angiography, except for a 70%-99% symptomatic stenosis. CONCLUSION: Primary studies should distinguish ipsilateral from contralateral arteries and carefully describe the patients' characteristics and study environment. The literature overestimates noninvasive imaging accuracy. More data are needed to inform physicians in routine clinical practice. |
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Authors:
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Francesca M Chappell; Joanna M Wardlaw; Gavin R Young; Jonathan H Gillard; Giles H Roditi; Brigitte Yip; Jill P Pell; Peter M Rothwell; Martin M Brown; Michael J Gough; Marc S Randall |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't Date: 2009-03-10 |
Journal Detail:
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Title: Radiology Volume: 251 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-29 Completed Date: 2009-05-28 Revised Date: 2009-10-29 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 493-502 Citation Subset: AIM; IM |
Affiliation:
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Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh EH42XU, Scotland. francesca.chappell@ed.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiography
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methods* Carotid Stenosis / diagnosis* Contrast Media* Humans Magnetic Resonance Imaging / methods* Reproducibility of Results Sensitivity and Specificity Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
| Comments/Corrections | |
Comment In:
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Radiology. 2009 May;251(2):311-2
[PMID:
19401566
]
Ann Intern Med. 2009 Oct 20;151(8):JC4-15 [PMID: 19841452 ] Radiology. 2009 Nov;253(2):570; author reply 570-1 [PMID: 19864532 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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