| Carotid artery intima-media thickness in nonalcoholic fatty liver disease. | |
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MedLine Citation:
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PMID: 18187076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate, in patients with nonalcoholic fatty liver disease with no or mild alterations of liver function tests, carotid artery intima-media thickness and the presence of plaques and to define determinants of vascular damage. METHODS: A paired-sample case-control study: 125 patients with nonalcoholic fatty liver disease and 250 controls, without a prior diagnosis of diabetes, hypertension, and cardiovascular disease, matched for sex, age, and body mass index. B-mode ultrasound was used for evaluation of carotid intima-media thickness and presence of small plaques. RESULTS: A significant difference in mean values of intima-media thickness (0.89+/-0.26 and 0.64+/-0.14 mm, P = .0001) and prevalence of plaques (26 [21%] and 15 [6%], P < .001) was observed in nonalcoholic fatty liver disease patients and controls. Variables significantly associated with intima-media thickness higher than 0.64 mm (median value in controls), in both patients and controls were: age (P = .0001), systolic blood pressure (P = .004), total and low-density lipoprotein cholesterol (P < or = .02 and P = .01, respectively), fasting glucose (P = .0001), and cardiovascular risk (P = .0001) and, only in controls, metabolic syndrome (P = .0001), HOMA-insulin resistance (P = .01), and body mass index (P = .0003). At multivariate logistic regression performed in the overall series of subjects, independent risk predictors of intima-media thickness higher than 0.64 mm were presence of steatosis (odds ratio [OR] = 6.9), age (OR 6.0), and systolic blood pressure (OR 2.3). CONCLUSION: Patients with nonalcoholic fatty liver disease, even with no or mild alterations of liver tests, should be considered at high risk for cardiovascular complications. |
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Authors:
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Anna Ludovica Fracanzani; Larry Burdick; Sara Raselli; Paola Pedotti; Liliana Grigore; Gennaro Santorelli; Luca Valenti; Alessandra Maraschi; Alberico Catapano; Silvia Fargion |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of medicine Volume: 121 ISSN: 1555-7162 ISO Abbreviation: Am. J. Med. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-11 Completed Date: 2008-01-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: United States |
Other Details:
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Languages: eng Pagination: 72-8 Citation Subset: AIM; IM |
Affiliation:
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Centro Malattie Metaboliche del Fegato, Dipartimento Medicina Interna, Università di Milano, Milano, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy Carotid Artery, Common / ultrasonography* Fatty Liver / blood, diagnosis* Female Follow-Up Studies Humans Male Middle Aged Prognosis Retrospective Studies Risk Factors Severity of Illness Index Tunica Intima / ultrasonography* |
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