| Carotid artery intima-media thickness and angiotensin-converting enzyme gene polymorphism in the offspring of parents with premature stroke. | |
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MedLine Citation:
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PMID: 15858957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To determine some common cardiovascular risk factors, alterations in the measurements of intima-media thickness (IMT) and the distribution of the angiotensin-converting enzyme (ACE) polymorphism in children of parents with premature stroke, and to investigate the cardiovascular risk of these children and the potential need for some preventive measures. METHODS: A family history of cardiovascular disease represents a cardiovascular risk factor in the offspring. This association has not yet been clearly determined for cerebrovascular accidents. New technology allows us to investigate the risk for cardiovascular disease at an early presymptomatic stage. We applied the measurement of IMT of carotid arteries by ultrasound imaging and the determination of the ACE insertion/deletion (I/D) polymorphism in blood to evaluate the predisposition for cerebrovascular disease in the offspring of patients with previous stroke. We investigated 58 subjects whose parents had experienced a cerebrovascular accident before the age of 45 y and compared them with a matched control group whose parents had not suffered a stroke. RESULTS: The results of IMT at various sites of the carotid arteries and the genotype distribution of the ACE gene were not significantly different between the study group and the control group. In addition, no differences were found in the serum levels of lipid fractions or other biochemical variables. CONCLUSION: We conclude that determination of the carotid IMT and of the ACE I/D polymorphism do not permit discrimination of the cardiovascular risk in children of parents with or without premature stroke. |
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Authors:
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N Marcun Varda; B Peterlin; S Umek Bradac; A Gregoric |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 94 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-04-29 Completed Date: 2005-06-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 33-7 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Maribor Teaching Hospital, Maribor, Slovenia. aleksander.varda@amis.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age of Onset Carotid Artery, Common / ultrasonography* Case-Control Studies Child Female Gene Frequency Genotype Humans Male Peptidyl-Dipeptidase A / genetics* Polymorphism, Genetic / genetics* Risk Factors Stroke / genetics* Tunica Intima / ultrasonography* Tunica Media / ultrasonography* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.15.1/Peptidyl-Dipeptidase A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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