| Carotid artery intima-media thickness and lacunar versus nonlacunar infarcts. | |
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MedLine Citation:
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PMID: 11872889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Increases in the thickness of the intima and media of the carotid artery have been associated with an increased risk of myocardial infarction and stroke in subjects without a history of cardiovascular disease. Lacunar infarcts, one of the most common subtype of ischemic stroke, show unique pathological and clinicoradiological characteristics. The present study examines the relationship between vascular risk factors, including carotid artery intima-media thickness (IMT), and lacunar versus nonlacunar infarcts. METHODS: We collected data from patients with acute ischemic stroke admitted to hospital. Patients and 129 control subjects underwent B-mode ultrasonographic measurements of IMT of the common carotid artery. We examined the association of lacunar and nonlacunar infarcts with age, sex, and potential vascular risk factors. RESULTS: Of 292 adult patients with an acute first-ever ischemic stroke, 96 were considered lacunar and 196 were considered nonlacunar strokes. We did not find a significantly different percentage of diabetes, smoking, hypertension, dyslipidemia, myocardial infarction, and previous transient ischemic attack between the 2 groups of patients. The multinomial logistic regression procedure selected carotid artery IMT and atrial fibrillation as the only independent factors able to discriminate between lacunar and nonlacunar patients. IMT values were significantly higher in patients with nonlacunar stroke versus both those with lacunar stroke and control subjects. CONCLUSIONS: The present results indicate the usefulness of noninvasive measurement of IMT with ultrasonic techniques as a diagnostic tool that may help to identify different subtypes of ischemic stroke patients. The noninvasive measurements may have predictive power with respect to lacunar versus nonlacunar infarcts. |
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Authors:
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L M Cupini; P Pasqualetti; M Diomedi; F Vernieri; M Silvestrini; B Rizzato; F Ferrante; G Bernardi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 33 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-03-01 Completed Date: 2002-03-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 689-94 Citation Subset: IM |
Affiliation:
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Clinica Neurologica, Ospedale S.Eugenio, Universita' di Roma Tor Vergata, Roma, Italy. lecupini@tin.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Age Distribution Aged Aged, 80 and over Brain Infarction / classification*, diagnosis*, epidemiology Carotid Artery, Common / ultrasonography* Cross-Sectional Studies Female Humans Logistic Models Male Middle Aged Predictive Value of Tests Risk Factors Sex Distribution Tunica Intima / ultrasonography* Tunica Media / ultrasonography* Ultrasonography, Doppler, Color |
| Comments/Corrections | |
Comment In:
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Stroke. 2003 Dec;34(12):e232-3; author reply e232-3
[PMID:
14615608
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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