Document Detail

Carotid arterial compliance in patients with congestive heart failure secondary to idiopathic dilated cardiomyopathy.
MedLine Citation:
PMID:  7942527     Owner:  NLM     Status:  MEDLINE    
Conduit artery distensibility affects the pulsatile component of afterload and may contribute to impaired left ventricular function in patients with congestive heart failure (CHF). The objectives of this study were to (1) determine whether arterial distensibility is reduced in patients with CHF, and (2) determine whether decreased arterial compliance is related to an abnormality in vascular wall structure (i.e., wall thickness or excessive levels of circulating neurohumoral vasoconstrictors, or both). The study participants included 40 patients with CHF secondary to idiopathic dilated cardiomyopathy and 33 age-matched healthy volunteers. High-resolution ultrasonography was performed to directly visualize the common carotid artery and measure its diameter and wall thickness. Its elastic properties were determined by relating changes in arterial diameter to changes in pressure generated with each heart beat. Carotid artery distensibility was less (14.1 +/- 1.1 vs 25.3 +/- 1.6 10(-6).N-1.m2, p < 0.001) and Young's modulus of elasticity was greater (3.99 +/- 0.51 vs 2.29 +/- 0.23 10(5).N.m-2, p < 0.005) in patients with CHF than in normal subjects. Also, carotid artery wall thickness was increased in patients with CHF. When the entire population was considered, age, wall thickness, and plasma norepinephrine and aldosterone concentrations correlated inversely with distensibility, whereas age and plasma norepinephrine concentration correlated directly with elasticity. Among normal subjects, only age correlated inversely with distensibility; among patients with CHF, only plasma norepinephrine concentration correlated with elasticity. It is concluded that carotid artery distensibility is reduced in patients with CHF.(ABSTRACT TRUNCATED AT 250 WORDS)
S G Lage; L Kopel; M C Monachini; C J Medeiros; F Pileggi; J F Polak; M A Creager
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  74     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-10-26     Completed Date:  1994-10-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  691-5     Citation Subset:  AIM; IM    
Heart Institute, School of Medicine, University of São Paulo, Brazil.
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MeSH Terms
Aldosterone / blood
Cardiomyopathy, Dilated / blood,  complications*
Carotid Artery, Common / pathology,  physiopathology*,  ultrasonography
Heart Failure / etiology,  physiopathology*,  ultrasonography
Middle Aged
Norepinephrine / blood
Regression Analysis
Grant Support
Reg. No./Substance:
51-41-2/Norepinephrine; 52-39-1/Aldosterone

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