| Carotid Intima-Media Thickness and Arterial Stiffness in Type 1 Diabetic Patients are Dependent on Age and Mean Blood Pressure. | |
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MedLine Citation:
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PMID: 21031337 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIM: The aim of the study was to assess the factors that influence carotid intima-media thickness (CIMT) and arterial stiffness in type 1 diabetic patients. MATERIAL AND METHODS: We included 87 type 1 diabetic patients (44 women, 43 men), median age 34 years, disease duration 10 years, HbA1c 8.2%. CIMT was measured using high resolution ultrasonography. Arterial stiffness was assessed with the use of digital volume pulse analysis and tonometric measurement of wave reflection and central haemodynamics. Serum C-reactive protein (hsCRP), matrix metalloproteinase-9 (MMP-9), soluble intracellular adhesion molecule-1 (sICAM-1) and myeloperoxidase (MPO) concentrations were also measured. RESULTS: CIMT and arterial stiffness correlated with age, duration of diabetes, systolic and diastolic blood pressure, GFR-glomerular filtration rate and sICAM-1. Multiple regression analysis identified only age as significant determinant of CIMT. Age, mean blood pressure and GFR, but not duration of diabetes were significant determinants of arterial stiffness. CONCLUSIONS: In type 1 diabetic patients both CIMT and arterial stiffness were related to age, blood pressure, kidney function and sICAM-1 serum concentration. |
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Authors:
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A Rogowicz-Frontczak; A Araszkiewicz; S Pilacinski; D Zozulinska-Ziolkiewicz; A Wykretowicz; B Wierusz-Wysocka |
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Publication Detail:
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Type: Journal Article Date: 2010-10-28 |
Journal Detail:
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Title: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Volume: 119 ISSN: 1439-3646 ISO Abbreviation: Exp. Clin. Endocrinol. Diabetes Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505926 Medline TA: Exp Clin Endocrinol Diabetes Country: Germany |
Other Details:
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Languages: eng Pagination: 281-5 Citation Subset: IM |
Copyright Information:
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznan, Poland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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