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Carotid IMT Variability (IMTV) and Its Validation in Symptomatic versus Asymptomatic Italian Population: Can This Be a Useful Index for Studying Symptomaticity?
MedLine Citation:
PMID:  22748012     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The carotid intima-media thickness (IMT) is a validated marker of cerebrovascular disease risk. This paper presents a new parameter, the IMT variability (IMTV), and compares it between symptomatic and asymptomatic patients taken from a cohort of Italian population. One hundred forty-two patients were analyzed (age 59 ± 112 years, 59% males), 42 of these patients suffered from TIA or minor stroke. The lumen-intima (LI) and media-adventitia (MA) interfaces of the far wall were manually traced by a Reader. We also used a computer-based automated system (called AutoEdge) to obtain the LI/MA interfaces. The LI/MA interfaces were used to measure the IMT and the IMTV along the distal wall of the common carotid artery. Wilcoxon and Pearson correlation analyses were performed. The agreement between the Reader's IMT and the AutoEdge IMT values was 98.7% for the symptomatic (0.83 ± 0.44 mm for Reader, 0.82 ± 0.35 mm for AutoEdge) and 94.9% for the asymptomatic patients (0.78 ± 0.45 mm for Reader, 0.74 ± 0.30 mm for AutoEdge). Correlation was 65% for symptomatic and 68% for asymptomatic patients, respectively. The IMT measured using AutoEdge was 1.2% lower compared to manual measurements in symptomatic population, while 5.12% lower in asymptomatic. The IMTV was 11% higher in symptomatic patients compared to asymptomatic when using manual delineations, 8% higher when using AutoEdge. There was no statistical difference between the manual and automated IMTV measurements (Wilcoxon signed rank, P > 0.7). We conclude that the IMT and IMTV values were very similar between Reader and AutoEdge software when studying symptomatic and asymptomatic patients in Italian population. (Echocardiography 2012;**:1-9).
Authors:
Luca Saba; Kristen M Meiburger; Filippo Molinari; Giuseppe Ledda; Michele Anzidei; U Rajendra Acharya; Guang Zeng; Shoaib Shafique; Andrew Nicolaides; Jasjit S Suri
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-2
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  -     ISSN:  1540-8175     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012, Wiley Periodicals, Inc.
Affiliation:
Department of Radiology, A.U.O. Cagliari, Cagliari, Italy Biolab, Department of Electronics and Telecommunications, Politecnico di Torino, Torino, Italy Department ECE, Ngee Ann Polytechnic, Singapore, Singapore MBF Bioscience, Williston, Vermont Department of Surgery, Section of Vascular Surgery, IU School of Medicine, Indianapolis, Indiana Vascular Diagnostic Center, Nicosia, Cyprus CTO, Diagnostic and Monitoring Division, AtheroPoint LLC, Roseville, California Biomedical Engineering Division, Biomedical Technologies Inc., Roseville, California Biomedical Engineering Department, Idaho State University, Pocatello, Idaho.
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