Document Detail

Carotid Baroreceptor Stimulation Prevents Arrhythmias Induced by Acute Myocardial Infarction through Autonomic Modulation.
MedLine Citation:
PMID:  24979392     Owner:  NLM     Status:  Publisher    
: Electrical carotid baroreceptor stimulation (CBS) has shown therapeutic potential for resistant hypertension and heart failure by resetting autonomic nervous system, but the impacts on arrhythmias remains unclear. The present study evaluated the effects of CBS on ventricular electrophysiological properties in normal dog heart and arrhythmias following acute myocardial infarction (AMI). In the acute protocol anesthetized open chest dogs were exposed to 1 hour left anterior descending coronary occlusion, as AMI model. Dogs were received either sham treatment (Control group, n=8) or CBS (CBS group, n=8), started 1 hour before AMI. CBS resulted in pronounced prolongation of ventricular effective refractory period and reduction of the maximum action potential duration restitution slope (from 0.85±0.15 in the baseline state to 0.67±0.09 at the end of 1 hour, P<0.05) before AMI. Number of premature ventricular contractions (277±168 in the Control group vs 103±84 in the CBS group, P<0.05) and episodes of ventricular tachycardia/ventricular fibrillation (7±3 in the Control group vs 3±2 in the CBS group P<0.05) was decreased compared with the control group during AMI. CBS buffered low frequency/high frequency ratio raise during AMI. Ischemic size was not affected by CBS. CBS may have a beneficial impact on ventricular arrhythmias induced by AMI through modulation of autonomic tone.
Kai Liao; Lilei Yu; Bo He; Bing Huang; Kang Yang; Gaowa Saren; Songyun Wang; Xiaoya Zhou; Hong Jiang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-23
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  -     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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