Document Detail


Carotid artery stenosis as a cause of stroke.
MedLine Citation:
PMID:  23075828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Population-based studies have estimated that about 15% of ischemic strokes are caused by large-vessel cerebrovascular disease. We determined the types of large-vessel atherosclerosis responsible for ischemic strokes in a population-based stroke study.
METHODS: Patients with first-ever or recurrent ischemic stroke in the Greater Cincinnati area were identified during 2005 at all local hospitals. Study physicians assigned ischemic stroke subtypes. Overall event rates and incidence rates for first-ever events were calculated, and age-, race- and sex-adjusted to the 2000 US population.
RESULTS: There were 2,204 ischemic strokes, including 365 strokes of large-vessel subtype (16.6% of all ischemic strokes). Extracranial internal carotid artery (ICA) stenosis was associated with 8.0% of all ischemic strokes, while extracranial ICA occlusion and intracranial atherosclerosis were each associated with 3.5% of strokes. The annual rate of first-ever and recurrent stroke attributed to extracranial ICA was 13.4 (11.4-15.4) per 100,000 persons. We conservatively estimate that about 41,000 strokes may be attributed to extracranial ICA stenosis annually in the United States.
CONCLUSIONS: Large-vessel atherosclerosis is an important cause of stroke, with extracranial ICA stenosis being significantly more common than extracranial ICA occlusion or intracranial atherosclerotic disease.
Authors:
Matthew L Flaherty; Brett Kissela; Jane C Khoury; Kathleen Alwell; Charles J Moomaw; Daniel Woo; Pooja Khatri; Simona Ferioli; Opeolu Adeoye; Joseph P Broderick; Dawn Kleindorfer
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2012-10-11
Journal Detail:
Title:  Neuroepidemiology     Volume:  40     ISSN:  1423-0208     ISO Abbreviation:  Neuroepidemiology     Publication Date:  2013  
Date Detail:
Created Date:  2012-12-21     Completed Date:  2013-10-17     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  8218700     Medline TA:  Neuroepidemiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  36-41     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
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MeSH Terms
Descriptor/Qualifier:
Carotid Stenosis / diagnosis*,  epidemiology*
Female
Hospitalization / trends
Humans
Male
Ohio / epidemiology
Population Surveillance* / methods
Stroke / diagnosis*,  epidemiology*
Grant Support
ID/Acronym/Agency:
1U01NS069763/NS/NINDS NIH HHS; 2P50NS044283/NS/NINDS NIH HHS; 5R01NS0678/NS/NINDS NIH HHS; 5U01NS062851/NS/NINDS NIH HHS; 5U10NS058982/NS/NINDS NIH HHS; 5UO1NS052220/NS/NINDS NIH HHS; K23NS049463/NS/NINDS NIH HHS; K23NS059843/NS/NINDS NIH HHS; MM-0971-07/07//PHS HHS; P50 NC 44283//PHS HHS; P50 NS044283/NS/NINDS NIH HHS; R-01-NS030678/NS/NINDS NIH HHS; R01 AR055563/AR/NIAMS NIH HHS; R01 AR056259/AR/NIAMS NIH HHS; R01 DK68463/DK/NIDDK NIH HHS; R01 ES015517/ES/NIEHS NIH HHS; R01 NS 30678/NS/NINDS NIH HHS; R01 NS030678/NS/NINDS NIH HHS; R01N0S36695//PHS HHS; R01ND039987/ND/ONDIEH CDC HHS; R01NS030678/NS/NINDS NIH HHS; R01NS036695/NS/NINDS NIH HHS; R01NS039512/NS/NINDS NIH HHS; R01NS042167/NS/NINDS NIH HHS; R01NS044876/NS/NINDS NIH HHS; R01NS052220/NS/NINDS NIH HHS; R01NS069208/NS/NINDS NIH HHS; R01NS30678/NS/NINDS NIH HHS; R01NS39512/NS/NINDS NIH HHS; R03CA142099/CA/NCI NIH HHS; U01 NS041588/NS/NINDS NIH HHS; U01 NS058728/NS/NINDS NIH HHS; U01NS052220/NS/NINDS NIH HHS; U01NS056975/NS/NINDS NIH HHS; U01NS069763/NS/NINDS NIH HHS; UL1 RR026/RR/NCRR NIH HHS
Comments/Corrections

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