Document Detail


Carotenoids from in ovo or dietary sources blunt systemic indices of the inflammatory response in growing chicks (Gallus gallus domesticus).
MedLine Citation:
PMID:  16549469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lutein, a dihydroxycarotenoid, has antioxidant and immunomodulatory potential. Two 2 x 2 x 2 factorial designs examined effects of carotenoids during in ovo embryogenesis and, in the diet posthatch, on the systemic inflammatory response to lipopolysaccharide (LPS). In both trials, breeder hens were fed a carotenoid-replete (40 mg lutein/kg) or a carotenoid-deplete diet, eggs were collected, and chicks were hatched from carotenoid-deplete or carotenoid-replete eggs. Meat-type chicks (n = 160 and n = 144, respectively) were then fed diets containing 0 or 40 mg lutein/kg diet and either injected or not injected with LPS. LPS injection increased plasma haptoglobin and Zn (P < 0.01) and reduced plasma Fe and Cu (P < 0.01). Chicks hatched from carotenoid-deplete eggs had greater changes in plasma Fe and S post-LPS than chicks hatched from carotenoid-replete eggs (P < 0.05 for each). Compared with chicks fed 40 mg lutein/kg diet, chicks fed 0 mg lutein had greater body weight losses and higher plasma haptoglobin and relative thymus, bursa, and spleen weights post-LPS (P < 0.05). Data suggest that a lack of carotenoid exposure, either in ovo or posthatch, increases parameters of systemic inflammation.
Authors:
Elizabeth A Koutsos; Juan Carlos García López; Kirk C Klasing
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  136     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-21     Completed Date:  2006-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1027-31     Citation Subset:  IM    
Affiliation:
Department of Animal Science, California Polytechnic State University, San Luis Obispo, CA 93407, USA. ekoutsos@calpoly.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Bursa of Fabricius / anatomy & histology
Carotenoids / administration & dosage*
Chick Embryo*
Chickens / growth & development*
Copper / blood
Diet / veterinary*
Female
Haptoglobins / analysis
Inflammation / chemically induced,  prevention & control,  veterinary*
Iron / blood
Lipopolysaccharides / administration & dosage
Lutein / administration & dosage
Organ Size
Poultry Diseases / chemically induced,  prevention & control*
Spleen / anatomy & histology
Sulfur / blood
Thymus Gland / anatomy & histology
Weight Loss
Zinc / blood
Chemical
Reg. No./Substance:
0/Haptoglobins; 0/Lipopolysaccharides; 127-40-2/Lutein; 36-88-4/Carotenoids; 7439-89-6/Iron; 7440-50-8/Copper; 7440-66-6/Zinc; 7704-34-9/Sulfur

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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