| Carotenoid depletion in serum of young type-1 diabetics fed low-carotenoid diets. | |
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MedLine Citation:
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PMID: 15331884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Type-1 diabetics have been considered to be at risk for increased oxidative stress which has been implicated in the development of long-term diabetes complications. Evidence suggests that antioxidant activity may be an important mechanism by which carotenoids could confer protection in human health. Our aim was to compare the serum carotenoid depletion rate in type-1 diabetics and control subjects consuming low-carotenoid diets. METHODS: Ten type-1 diabetics and 8 controls followed a very low-carotenoid diet for 21 days. Dietary intake was recorded daily and fasting blood samples collected at baseline and after 1, 2, 3, 6, 11, 15, 16, 17, and 21 days. Individual carotenoids in serum were analyzed by a validated HPLC method. RESULTS: In both groups, carotenoid intake was less than 5% of the season-adjusted carotenoid reference intake. These diets resulted in decreased serum carotenoid levels in both groups, although depletion curves, final mean concentrations and the estimated half-life of carotenoids in serum revealed no differences between type-1 diabetics and controls. Levels of other minor serum carotenoids, cis-isomers and keto-carotenoids, also decreased whereas serum retinol and alpha- and gamma-tocopherol did not change during the study. CONCLUSION: Upon a low-carotenoid intake, the depletion rate of carotenoids in serum in young type-1 diabetics does not differ from that observed in matched related controls. |
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Authors:
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F Granado; B Olmedilla; I Blanco |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-08-25 |
Journal Detail:
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Title: Annals of nutrition & metabolism Volume: 48 ISSN: 0250-6807 ISO Abbreviation: Ann. Nutr. Metab. Publication Date: 2004 |
Date Detail:
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Created Date: 2004-10-15 Completed Date: 2005-04-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8105511 Medline TA: Ann Nutr Metab Country: Switzerland |
Other Details:
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Languages: eng Pagination: 251-8 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2004 S. Karger AG, Basel. |
Affiliation:
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Unidad de Vitaminas, Servicio de Endocrinología y Nutrición, Hospital Universitario Puerta de Hierro, Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antioxidants / analysis*, metabolism Carotenoids / administration & dosage*, blood*, deficiency Chromatography, High Pressure Liquid Diabetes Mellitus, Type 1 / blood* Diet* Fasting Female Humans Male Xanthophylls beta Carotene / analogs & derivatives*, blood |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Xanthophylls; 36-88-4/Carotenoids; 472-70-8/cryptoxanthin; 502-65-8/lycopene; 7235-40-7/beta Carotene |
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