Document Detail

Carotenodermia in men with elevated carotenoid intake from foods and beta-carotene supplements.
MedLine Citation:
PMID:  3421202     Owner:  NLM     Status:  MEDLINE    
We evaluated the relation between plasma levels of carotenoids and carotenodermia in 30 men receiving carotenoid supplementation for 42 d. Five subjects each were randomly assigned to one of six treatment groups: 30 mg purified beta-carotene supplement, 12 mg beta-carotene supplement, 272 g cooked carrots, 300 g cooked broccoli, 180 g tomato juice, and placebo. Definite carotenodermia was observed only in the five subjects who took 30 mg of purified beta-carotene daily. Carotenodermia was first noted between 25 and 42 d after supplementation and persisted from 14 to greater than 42 d posttreatment and was observed only after plasma total carotenoid levels exceeded 4.0 mg/L. These observations may be useful to investigators planning clinical trials with beta-carotene and to clinicians assessing the significance of carotenodermia in men taking beta-carotene supplements or following diets high in carotenoid-containing foods.
M S Micozzi; E D Brown; P R Taylor; E Wolfe
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  48     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-10-27     Completed Date:  1988-10-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1061-4     Citation Subset:  AIM; IM    
Medical Museum, Armed Forces Institute of Pathology, Washington, DC 20306-6000.
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MeSH Terms
Carotenoids / administration & dosage*,  blood*
Dose-Response Relationship, Drug
Skin Pigmentation / drug effects*
beta Carotene
Reg. No./Substance:
0/Capsules; 36-88-4/Carotenoids; 7235-40-7/beta Carotene
Comment In:
Am J Clin Nutr. 1989 Jun;49(6):1330-1   [PMID:  2729174 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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