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CARNITINE SUPLEMENTATION EFFECTS ON NON-ENZYMATIC ANTIOXIDANTS IN YOUNG RATS SUBMITTED TO EXHAUSTIVE EXERCISE STRESS.
MedLine Citation:
PMID:  21912289     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Previous studies demonstrated that exercise stress increase oxidative stress in rats. However, antioxidant supplement therapy effects on reactive oxygen substances are conflicting. We evaluated the effects of carnitine on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress. Wistar rats were divided into three groups: 1) control group (not submitted to exercise stress); 2) exercise stress group and; 3) exercise stress and carnitine group. Rats from the group 3 were treated with gavage administration of 1 mL of carnitine (5mg/kg) for seven consecutive days. Animals from groups 2 and 3 were submitted to a bout of swimming exhaustive exercise stress. Kidney samples were analyzed for Reactive Substances to Thiobarbituric Acid (SRATB) by malondialdehyde (MDA), reduced glutathione (GSH) and vitamin-E levels. Carnitine treatment attenuated MDA increase caused by exercise stress (1: 0.16±0.02mmmol/mgprot vs. 2: 0.34±0.07 mmmol/mgprot vs. 3: 0.1±0.01 mmmol/mgprot; p<0.0001). It also increased renal levels of GSH (1: 23±4μmol/gprot vs. 2: 23±2 μmol/gprot vs. 3: 58±9 μmol/gprot; p<0.0001), however, it did not change renal vitamin E (1: 24±5μM/gtissue vs. 2: 27±1 μM/gtissue vs. 3: 28±5 μM/gtissue; p<0.001). In conclusion, carnitine improved oxidative stress and partially improved non-enzymatic antioxidant activity in young rats submitted to exhaustive exercise stress.
Authors:
Sérvio A Bucioli; Luiz Carlos de Abreu; Vitor E Valenti; Helio Vannucchi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-09
Journal Detail:
Title:  Journal of strength and conditioning research / National Strength & Conditioning Association     Volume:  -     ISSN:  1533-4287     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9415084     Medline TA:  J Strength Cond Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Laboratório de Química e Bioquímica de Alimentos, Universidade de São Paulo (USP), São Paulo, SP, Brasil.; 2Departamento de Morfologia e Fisiologia, Faculdade de Medicina do ABC, Santo André, SP, Brasil.; 3Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
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