Document Detail

Carnitine levels in patients with chronic rheumatic heart disease.
MedLine Citation:
PMID:  9455619     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Carnitine, a small aminoacid derivative plays a major role in fatty acid oxidation. Myocardial carnitine deficiency may cause malfunction of the heart. Rheumatic valvular heart disease can be associated with myocardial dysfunction. We have investigated myocardial and plasma-free carnitine levels in patients with chronic rheumatic heart disease. MATERIAL AND METHODS: Eleven patients with chronic rheumatic heart disease requiring valve replacement were selected for study. Ten patients with no cardiac failure, myocardial wall motion abnormalities and myocardial infarction and for whom coronary bypass surgery was planned were selected as the control group. Carnitine levels of myocardial tissue obtained from the right atrium and plasma during the operation were evaluated using spectrophotometric method. Myocardial-free carnitine levels expressed as mumol/g (dry weight) were determined according to Ceberblad and Lindstedt technique. RESULTS: Myocardial-free carnitine levels in patients were found to be 0.72 +/- 0.37 mumol/g (dry weight) in comparison with 1.44 +/- 1.03 mumol/g (dry weight) in the control group. Myocardial-free carnitine levels in patients were statistically decreased when compared to control group. Plasma-free carnitine levels in patients were 80.91 +/- 28.22 mumol/L and 89.52 +/- 48.21 mumol/L in the control group, respectively. There was no significant difference between plasma-free carnitine levels of the groups. CONCLUSION: In our study, myocardial-free carnitine levels were decreased while plasma-free carnitine levels were normal in patient with chronic rheumatic heart disease.
F Narin; N Narin; H Andaç; A Ergin; A Coşkun; M Ustdal; H Ceyran
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical biochemistry     Volume:  30     ISSN:  0009-9120     ISO Abbreviation:  Clin. Biochem.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-03-06     Completed Date:  1998-03-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  643-5     Citation Subset:  IM    
Erciyes University Medical Faculty, Department of Biochemistry, Kayseri, Türkiye.
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MeSH Terms
Carnitine / metabolism*
Chronic Disease
Middle Aged
Rheumatic Heart Disease / metabolism*
Reg. No./Substance:

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