| Carnitine deficiency-induced cardiomyopathy. | |
| | |
MedLine Citation:
|
PMID: 9546628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The results of clinical and animal studies suggest that a short term period of moderate secondary carnitine deficiency, in and of itself, does not have a major effect on the cardiac contractile function, although substrate oxidation may be altered. However, with longer durations of carnitine deficiency, alterations occur within the heart that may result in impaired contractile performance, particularly at high workloads. At this point, the mechanisms responsible for the cardiac depression are uncertain. We hypothesize that the alterations in substrate metabolism produced by the carnitine deficient state results in inadequate ATP production under high workload conditions which result in impaired cardiac contractile performance. Carnitine deficiency may also induce a number of changes in gene expression of key enzymes required for normal cardiac contractile function and metabolism. |
| | |
Authors:
|
D J Paulson |
Related Documents
:
|
167148 - Effects of verapamil on myocardial contractility, cardiac adenosine 3,'5'-monophosphate... 22949478 - Utility of framingham coronary heart disease risk score for predicting cardiac risk aft... 10392878 - Study of myocardial contractility by pulsed wave doppler tissue imaging does not reveal... 23632968 - Loss of mir-29b following acute ischemic stroke contributes to neural cell death and in... 14737048 - Three kinds of cosmophysical activity: links to temporal distribution of deaths and occ... 6305088 - Brain scintigraphy with tc99-pertechnetate in the evaluation of patients with cerebrova... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Molecular and cellular biochemistry Volume: 180 ISSN: 0300-8177 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 1998 Mar |
Date Detail:
|
Created Date: 1998-05-21 Completed Date: 1998-05-21 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 33-41 Citation Subset: IM |
Affiliation:
|
Department of Physiology, Midwestern University, Downers Grove, Illinois 60515, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardiomyopathies / etiology* Carnitine / deficiency* Disease Models, Animal Humans Kinetics Models, Biological Vitamin B Deficiency / complications* |
| Grant Support | |
ID/Acronym/Agency:
|
R15 HL54259/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
541-15-1/Carnitine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Differential regulation in the heart of mitochondrial carnitine palmitoyltransferase-I muscle and li...
Next Document: Fatty acid-binding proteins in the heart.