Document Detail


Carnitine deficiency-induced cardiomyopathy.
MedLine Citation:
PMID:  9546628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The results of clinical and animal studies suggest that a short term period of moderate secondary carnitine deficiency, in and of itself, does not have a major effect on the cardiac contractile function, although substrate oxidation may be altered. However, with longer durations of carnitine deficiency, alterations occur within the heart that may result in impaired contractile performance, particularly at high workloads. At this point, the mechanisms responsible for the cardiac depression are uncertain. We hypothesize that the alterations in substrate metabolism produced by the carnitine deficient state results in inadequate ATP production under high workload conditions which result in impaired cardiac contractile performance. Carnitine deficiency may also induce a number of changes in gene expression of key enzymes required for normal cardiac contractile function and metabolism.
Authors:
D J Paulson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  180     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-05-21     Completed Date:  1998-05-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  33-41     Citation Subset:  IM    
Affiliation:
Department of Physiology, Midwestern University, Downers Grove, Illinois 60515, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomyopathies / etiology*
Carnitine / deficiency*
Disease Models, Animal
Humans
Kinetics
Models, Biological
Vitamin B Deficiency / complications*
Grant Support
ID/Acronym/Agency:
R15 HL54259/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
541-15-1/Carnitine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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